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Anti-Phospho-Trk C (Y516) antibody

[STJ90960] Download PDF Print Data Sheet
5-7 days

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Product name Anti-Phospho-Trk C (Y516) antibody
Short Description Rabbit polyclonal to Phospho-Trk C (Y516).
Description Trk C is a protein encoded by the NTRK3 gene which is approximately 94,4 kDa. Trk C is localised to the cell membrane and is involved in apoptotic pathways in synovial fibroblasts, GPCR pathway, ERK signalling and apoptosis pathways. This protein falls under the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Trk C is widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain. Mutations in the NTRK3 gene are associated with susceptibility to congenital heart defects and differentiated thyroid carcinoma. STJ90960 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.This primary antibody specifically binds to endogenous Trk C protein which only binds about Y516 when Y516 is phosphorylated.
Applications ELISA, ICC, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Specificity Phospho-Trk C (Y516) Polyclonal Antibody detects endogenous levels of Trk C protein only when phosphorylated at Y516.
Protein Name NT-3 growth factor receptor
GP145-TrkC
Trk-C
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase
Immunogen Synthesized peptide derived from human Trk C around the phosphorylation site of Y516.
Immunogen Region 460-540 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4916
Gene Symbol NTRK3
Molecular Weight 160 kDa
Database Links HGNC:8033
OMIM:191316
Alternative Names Anti-Phospho-Trk C (Y516) antibody
Function Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Post-translational Modifications Ligand-mediated auto-phosphorylation.
Cellular Localization Membrane; Single-pass type I membrane protein.
Tissue Specificity Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Swiss-Prot Key Q16288_HUMAN
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