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Anti-Phospho-Trk C (Y516) antibody

[STJ90960] Download PDF Print Data Sheet

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Product name Anti-Phospho-Trk C (Y516) antibody
Short Description Rabbit Polyclonal to Phospho-Trk C (Y516).
Description Trk C is a protein encoded by the NTRK3 gene which is approximately 94,4 kDa. Trk C is localised to the cell membrane and is involved in apoptotic pathways in synovial fibroblasts, GPCR pathway, ERK signalling and apoptosis pathways. This protein falls under the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Trk C is widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain. Mutations in the NTRK3 gene are associated with susceptibility to congenital heart defects and differentiated thyroid carcinoma. STJ90960 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.This primary antibody specifically binds to endogenous Trk C protein which only binds about Y516 when Y516 is phosphorylated.
Applications IHC-p, ELISA, ICC, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:10000 /
Specificity Phospho-Trk C (Y516) Polyclonal Antibody detects endogenous levels of Trk C protein only when phosphorylated at Y516.
Protein Name NT-3 growth factor receptor - NTRK3 - TRKC - neurotrophic receptor tyrosine kinase 3
Immunogen Synthesized peptide derived from human Trk C around the phosphorylation site of Y516.
Immunogen Region 460-540 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4916 (Human) / 18213 (Mouse) / 29613 (Rat)
Gene Symbol NTRK3
Molecular Weight 160 kDa
Database Links Human UniProt/Swiss-Prot:Q16288 Mouse UniPort/Swiss-Prot: Q6VNS1 Rat UniProt/Swiss-Port: Q03351 Human Entrez Gene: 4916 Mouse Entrez Gene: 18213 Rat Entrez Gene: Rn.9963
Alternative Names NTRK3 / neurotrophic receptor tyrosine kinase 3 / A306_02810 antibody / AS27_00184 antibody / CB1_000370008 antibody / D623_10013164 antibody / Discoidin domain-containing receptor 2 antibody / ETS related protein-neurotrophic receptor tyrosine kinase fusion protein antibody / ETV6-NTRK3 fusion antibody / gp145-trkC antibody / gp145(trkC) antibody / H920_03957 antibody / hypothetical protein antibody / I79_021789 antibody / M959_13617 antibody / N300_13758 antibody / N301_04432 antibody / N302_16314 antibody / N303_10981 antibody / N306_12740 antibody / N307_02741 antibody / N308_02655 antibody / N309_09339 antibody / N310_02488 antibody / N311_03187 antibody / N312_07355 antibody / N320_11131 antibody / N321_01646 antibody / N324_02526 antibody / N326_01331 antibody / N327_02435 antibody / N330_01758 antibody / N331_13117 antibody / N332_06654 antibody / N333_10658 antibody / N335_12970 antibody / N336_10401 antibody / N341_00996 antibody / neural receptor protein-tyrosine kinase (trkC) antibody / neurotrophic tyrosine kinase receptor type 3 antibody / neurotrophic tyrosine kinase receptor / type 3 antibody / neurotrophic tyrosine kinase / receptor / type 3 antibody / neurotrophin-3 antibody / NT-3 growth factor receptor antibody / Ntrk3_tv3 antibody / PAL_GLEAN10009463 antibody / PANDA_008236 antibody / receptor tyrosine kinase antibody / TREES_T100002226 antibody / trk-C antibody / TRKC antibody / trkC tyrosine kinase antibody / tyrosine kinase C receptor / TrkC receptor / high-affinity neurotrophin receptor antibody / tyrosine kinase receptor C antibody / UY3_07601 antibody / Y1Q_024056 antibody / Y956_09729 antibody
Function Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Post-translational Modifications Ligand-mediated auto-phosphorylation.
Cellular Localization Membrane; Single-pass type I membrane protein.
Tissue Specificity Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

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