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Anti-PXR antibody

[STJ95276] Download PDF Print Data Sheet
Anti-PXR antibody

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Product name Anti-PXR antibody
Short Description Rabbit Polyclonal to PXR.
Description Rabbit Polyclonal to PXR.
Applications ELISA, WB
Dilution range WB 1:500-1:2000 / ELISA 1:40000 /
Specificity PXR Polyclonal Antibody detects endogenous levels of PXR protein.
Protein Name Nuclear receptor subfamily 1 group I member 2 - NR1I2 - ONR1 - PXR - BXR - SXR - PAR2 - nuclear receptor subfamily 1 group I member 2
Immunogen Synthesized peptide derived from human PXR
Immunogen Region 60-140 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 8856 (Human) /
Gene Symbol NR1I2
Molecular Weight 50 kDa
Database Links Human UniProt/Swiss-Prot:O75469 Mouse UniPort/Swiss-Prot: O54915 Rat UniProt/Swiss-Port: Q9R1A7 Human Entrez Gene: 8856 Mouse Entrez Gene: 18171 Rat Entrez Gene: Rn.207164
Alternative Names NR1I2 / nuclear receptor subfamily 1 group I member 2 / BXR antibody / CB1_001373019 antibody / D623_10031787 antibody / H920_07827 antibody / hypothetical protein antibody / mPXR antibody / nuclear receptor subfamily 1 / group 1 / member 2 antibody / nuclear receptor subfamily 1 / group I / member 2 antibody / nuclear receptor subfamily 1 group I member 2-like protein antibody / nuclear recptor subfamily 1 group I member 2 antibody / onr1 antibody / orphan nuclear receptor BXR-beta antibody / orphan nuclear receptor PAR1 antibody / orphan nuclear receptor PXR antibody / PAL_GLEAN10006517 antibody / PANDA_003272 antibody / par antibody / PAR1 antibody / PAR2 antibody / PARq antibody / pregnane X nuclear receptor variant 2 antibody / Pregnane X receptor antibody / pregnane X receptor (nuclear receptor sub family 1 / group I / member 2) antibody / PRR antibody / PXR antibody / PXR1 antibody / PXR.1 antibody / PXR.2 antibody / SAR antibody / steroid and xenobiotic receptor antibody / sxr antibody / TREES_T100015344 antibody / xonr1 antibody
Function Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Cellular Localization Nucleus
Tissue Specificity Expressed in liver, colon and small intestine.

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