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Anti-RHEB antibody

[STJ98588] Download PDF Print Data Sheet

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Product name Anti-RHEB antibody
Short Description Rabbit Polyclonal to RHEB.
Description RHEB is a protein encoded by the RHEB gene which is approximately 20,5 kDa. RHEB is localised to the cytoplasm, Golgi apparatus membrane, cytosol and endoplasmic reticulum membrane. It is involved in the regulation of lipid metabolism, insulin signalling-generic cascades, mTOR signalling, RET signalling, AMP-activated protein kinase signalling and the phospholipase D signalling pathway. The RHEB gene is a member of the small GTPase superfamily and encodes the lipid-anchored, cell membrane protein, RHEB. This protein is vital in regulation of growth and cell cycle progression. RHEB is ubiquitous expressed with highest levels observed in skeletal and cardiac muscle. Mutations in the RHEB can result in tuberous sclerosis. STJ98588 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody binds to endogenous levels of RHEB.
Applications ELISA, WB
Dilution range WB 1:500-2000 / ELISA 1:10000-20000
Specificity RHEB Polyclonal Antibody detects endogenous levels of RHEB
Protein Name RHEB - RHEB - RHEB2 - Ras homolog enriched in brain
Immunogen Synthesized peptide derived from synthetic peptide derived from RHEB.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Cow, Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 6009 (Human)
Gene Symbol RHEB
Database Links Human UniProt/Swiss-Prot:Q15382 Mouse UniPort/Swiss-Prot: Q921J2 Rat UniProt/Swiss-Port: Q62639 Human Entrez Gene: 6009 Mouse Entrez Gene: 19744 Rat Entrez Gene: Rn.859
Alternative Names RHEB / Ras homolog enriched in brain / A306_10582 antibody / AS27_08305 antibody / AS28_01754 antibody / CG1081-PA antibody / CG1081-PB antibody / Dmel_CG1081 antibody / DmRheb antibody / Dm Rheb antibody / DReb antibody / dRheb antibody / EH28_07626 antibody / GB16109 antibody / GTP-binding protein Rheb antibody / GTP-binding protein Rheb homolog antibody / GTP-binding protein Rheb-like protein antibody / H920_10967 antibody / hypothetical protein antibody / M91_02843 antibody / M959_04461 antibody / N300_13490 antibody / N301_12955 antibody / N302_04458 antibody / N303_03783 antibody / N305_11012 antibody / N306_13125 antibody / N307_06373 antibody / N308_12985 antibody / N309_07623 antibody / N310_09611 antibody / N311_11594 antibody / N312_03572 antibody / N320_08368 antibody / N322_04164 antibody / N324_03708 antibody / N325_00657 antibody / N326_03358 antibody / N327_05129 antibody / N328_10047 antibody / N329_05872 antibody / N330_04222 antibody / N331_01525 antibody / N332_11241 antibody / N333_06059 antibody / N334_04433 antibody / N335_13180 antibody / N339_11583 antibody / N340_06192 antibody / N341_04542 antibody / null antibody / PAL_GLEAN10007530 antibody / PANDA_003534 antibody / putative Ras homolog enriched in brain variant 1 antibody / Q9VND8 antibody / RAS-homolog enriched in brain antibody / Ras homolog enriched in brain 2 antibody / Ras homolog enriched in brain ortholog antibody / Ras homolog enriched in brain ortholog (H. sapiens) antibody / Ras homologue enriched in brain antibody / Ras homology enriched in brain antibody / Ras-like enriched in brain protein antibody / ras-related GTP binding protein antibody / Rheb1 antibody / rheb2 antibody / Rheb-PA antibody / Rheb-PB antibody / Y956_14091 antibody / Z169_01069 antibody
Function Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Post-translational Modifications Farnesylation is important for efficiently activating mTORC1-mediated signaling.; Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation.
Cellular Localization Endomembrane system Golgi apparatus membrane Cytoplasm, cytosol Endoplasmic reticulum membrane
Tissue Specificity Ubiquitous. Highest levels observed in skeletal and cardiac muscle.

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