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Anti-RHEB antibody

[STJ98588] Download PDF Print Data Sheet

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Product name Anti-RHEB antibody
Short Description Rabbit Polyclonal to RHEB.
Description RHEB is a protein encoded by the RHEB gene which is approximately 20,5 kDa. RHEB is localised to the cytoplasm, Golgi apparatus membrane, cytosol and endoplasmic reticulum membrane. It is involved in the regulation of lipid metabolism, insulin signalling-generic cascades, mTOR signalling, RET signalling, AMP-activated protein kinase signalling and the phospholipase D signalling pathway. The RHEB gene is a member of the small GTPase superfamily and encodes the lipid-anchored, cell membrane protein, RHEB. This protein is vital in regulation of growth and cell cycle progression. RHEB is ubiquitous expressed with highest levels observed in skeletal and cardiac muscle. Mutations in the RHEB can result in tuberous sclerosis. STJ98588 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody binds to endogenous levels of RHEB.
Applications ELISA, WB
Dilution range WB 1:500-2000
ELISA 1:10000-20000
Specificity RHEB Polyclonal Antibody detects endogenous levels of RHEB
Protein Name GTP-binding protein Rheb
Ras homolog enriched in brain
Immunogen Synthesized peptide derived from synthetic peptide derived from RHEB.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Cow, Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 6009
Gene Symbol RHEB
Database Links HGNC:10011
Alternative Names RHEB antibody
RHEB2 antibody
GTP-binding protein Rheb antibody
Ras homolog enriched in brain antibody
Function Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Post-translational Modifications Farnesylation is important for efficiently activating mTORC1-mediated signaling.; Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation.
Cellular Localization Endomembrane system Golgi apparatus membrane Cytoplasm, cytosol Endoplasmic reticulum membrane
Tissue Specificity Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Swiss-Prot Key Q15382_HUMAN


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