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Anti-Smo antibody

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Anti-Smo antibody

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Product name Anti-Smo antibody
Short Description Rabbit Polyclonal to Smo.
Description Rabbit Polyclonal to Smo.
Applications ELISA, WB
Dilution range WB 1:500-1:2000 / ELISA 1:10000 /
Specificity Smo Polyclonal Antibody detects endogenous levels of Smo protein.
Protein Name Smoothened homolog - SMO - FZD11 - SMOH - smoothened - frizzled class receptor
Immunogen Synthesized peptide derived from human Smo
Immunogen Region 40-120 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 6608 (Human) / 319757 (Mouse) / 25273 (Rat)
Gene Symbol SMO
Molecular Weight 50 kDa
Database Links Human UniProt/Swiss-Prot:Q99835 Mouse UniPort/Swiss-Prot: P56726 Rat UniProt/Swiss-Port: P97698 Human Entrez Gene: 6608 Mouse Entrez Gene: 319757 Rat Entrez Gene: Rn.44429
Alternative Names SMO / smoothened / frizzled class receptor / AS27_08681 antibody / AUGUSTUS-3.0.2_05545 antibody / bent body antibody / bnb antibody / CG11561-PA antibody / CHUNP6862 antibody / D623_10012836 antibody / Dmel_CG11561 antibody / dSmo antibody / frizzled family member 11 antibody / FZD11 antibody / GB10379 antibody / GLEAN_05545 antibody / Gx antibody / H920_09281 antibody / hypothetical protein antibody / M91_00886 antibody / MDA_GLEAN10013078 antibody / N300_03445 antibody / N301_08010 antibody / N302_04468 antibody / N303_07344 antibody / N305_14644 antibody / N306_04208 antibody / N307_09279 antibody / N325_11042 antibody / N330_06103 antibody / N332_01545 antibody / N333_08258 antibody / N335_08041 antibody / PAL_GLEAN10019145 antibody / PANDA_001292 antibody / protein Gx antibody / protein smoothened antibody / Putative adenosylhomocysteinase 3 antibody / seven transmembrane helix receptor antibody / slow muscle omitted antibody / Smoh antibody / smooth antibody / smoothene antibody / smoothened antibody / smoothened /frizzled class receptor antibody / smoothened / frizzled family receptor antibody / smoothened homolog antibody / smoothened homolog protein antibody / smoothened-like protein antibody / Smoothened like protein antibody / smoothened / seven transmembrane spanning receptor antibody / smo-PA antibody / smu antibody / TcasGA2_TC005545 antibody / XSmo antibody / X-smoothened antibody / Y1Q_002674 antibody / Z169_10037 antibody
Function G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia . Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
Cellular Localization Membrane Cell projection, cilium

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