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Anti-SUMO-1 antibody

[STJ95835] Download PDF Print Data Sheet

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Product name Anti-SUMO-1 antibody
Short Description Rabbit Polyclonal to SUMO-1.
Description SUMO-1 is a protein encoded by the SUMO1 gene which is approximately 11,6 kDa. SUMO-1 is localised to the nuclear membrane and nucelus. It is involved in SUMOylation, DNA double-strand break repair, transcription-coupled nucleotide excision repair and interferon gamma signalling. This protein falls under the SUMO protein family. It functions similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. This protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO-1 is expressed in the cells of the nervous system, liver, lung, kidney and blood. Mutations in the SUMO1 gene result in disease such as non-syndromic orofacial cleft 10 which is a birth defect exhibiting cleft lips which can range in severity and can occur on one or both sides. TJ95835 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody binds endogenous SUMO-1.
Applications IHC-p, ELISA, IF, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / IF 1:200-1:1000 / ELISA 1:20000 /
Specificity SUMO-1 Polyclonal Antibody detects endogenous levels of SUMO-1 protein.
Protein Name Small ubiquitin-related modifier 1 - SUMO1 - PIC1 - GMP1 - SMT3C - SUMO-1 - SMT3H3 - OFC10 - UBL1 - small ubiquitin-like modifier 1
Immunogen Synthesized peptide derived from human SUMO-1
Immunogen Region 1-80 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7341 (Human) / 22218 (Mouse) / 301442 (Rat)
Gene Symbol SUMO1
Molecular Weight 12 kDa
Database Links Human UniProt/Swiss-Prot:P63165 Mouse UniPort/Swiss-Prot: P63166 Rat UniProt/Swiss-Port: Q5I0H3 Human Entrez Gene: 7341 Mouse Entrez Gene: 22218 Rat Entrez Gene: Rn.1221
Alternative Names SUMO1 / small ubiquitin-like modifier 1 / A306_11060 antibody / AS27_04058 antibody / AS28_03254 antibody / D623_10008627 antibody / dap1 antibody / dap-1 antibody / fd12c02 antibody / GAP modifying protein 1 antibody / GMP1 antibody / H920_20297 antibody / hypothetical protein antibody / M91_06400 antibody / M959_04840 antibody / MDA_GLEAN10008492 antibody / N300_06682 antibody / N301_02470 antibody / N302_09783 antibody / N303_08500 antibody / N305_06723 antibody / N306_11822 antibody / N307_07756 antibody / N308_08463 antibody / N309_08062 antibody / N310_07522 antibody / N311_03971 antibody / N320_00806 antibody / N321_10335 antibody / N322_10274 antibody / N324_02842 antibody / N325_06232 antibody / N326_08857 antibody / N327_11632 antibody / N329_12456 antibody / N331_06338 antibody / N332_12811 antibody / N334_07491 antibody / N335_06196 antibody / N336_02658 antibody / N339_11435 antibody / N341_09189 antibody / OFC10 antibody / PAL_GLEAN10026127 antibody / PANDA_007777 antibody / PIC1 antibody / pigSUMO1 antibody / putative ubiquitin-like 1 antibody / senp2 antibody / sentrin antibody / small ubiquitin-related modifier-1 antibody / Small ubiquitin-related modifier 1 antibody / small ubiquitin-related modifier 1-like protein antibody / smt3 antibody / SMT3C antibody / SMT3H3 antibody / SMT3 homolog 3 antibody / SMT3 suppressor of mif two 3 homolog 1 antibody / SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) antibody / SMT3 suppressor of mif two 3 homolog 1 (yeast) antibody / SMT3 suppressor of mif two 3-like 1 antibody / SMTP3 antibody / SUMO-1 antibody / SUMO-1 related peptidase antibody / ubiquitin-homology domain protein PIC1 antibody / ubiquitin-like 1 antibody / ubiquitin-like 1-like antibody / ubiquitin-like 1 (sentrin) antibody / ubiquitin-like protein SMT3C antibody / ubiquitin-like protein UBL1 antibody / Ubl1 antibody / UY3_18568 antibody / xsumo1 antibody / xsumo-1 antibody / Y1Q_001220 antibody / Y956_07532 antibody / Z169_07008 antibody
Function Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 . Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 .
Post-translational Modifications Cleavage of precursor form by SENP1 or SENP2 is necessary for function.; Polymeric SUMO1 chains undergo polyubiquitination by RNF4.
Cellular Localization Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane Nucleus Note=Recruited by BCL11A into the nuclear body. In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.


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