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Anti-SV2C antibody

[STJ96442] Download PDF Print Data Sheet

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Product name Anti-SV2C antibody
Short Description Rabbit Polyclonal to SV2C.
Description SV2C is a protein encoded by the SV2C gene which is approximately 82,3 kDa. SV2C is localised to the cytoplasmic vesicle, secretory vesicle and synaptic vesicle membrane. It is involved in pathways such as the uptake and actions of bacterial toxins,the HIV life cycle and ECM-receptor interaction. It functions by controlling the regulation of secretion in neural and endocrine cells, enhancing low-frequency neurotransmission. It also positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. SV2C is expressed in the cells of the nervous system. Mutations in the SV2C gene result in alcohol-related birth defects and fetal alcohol spectrum disorder. STJ96442 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of SV2C protein.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC-P 1:100-300 / ELISA 1:20000 /
Specificity SV2C Polyclonal Antibody detects endogenous levels of SV2C protein.
Protein Name Synaptic vesicle glycoprotein 2C - SV2C - synaptic vesicle glycoprotein 2C
Immunogen Synthesized peptide derived from human SV2C.
Immunogen Region Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 22987 (Human) / 75209 (Mouse) / 29643 (Rat)
Gene Symbol SV2C
Molecular Weight 83 kDa
Database Links Human UniProt/Swiss-Prot:Q496J9 Mouse UniPort/Swiss-Prot: Q69ZS6 Rat UniProt/Swiss-Port: Q9Z2I6 Human Entrez Gene: 22987 Mouse Entrez Gene: 75209 Rat Entrez Gene: Rn.161757
Alternative Names SV2C / synaptic vesicle glycoprotein 2C / A306_04933 antibody / AS27_09929 antibody / AS28_06222 antibody / Ca2+ regulator SV2A-like protein antibody / CB1_000917001 antibody / D623_10035949 antibody / EGK_16603 antibody / GW7_20438 antibody / H920_03171 antibody / hypothetical protein antibody / I79_004641 antibody / N300_04341 antibody / N301_04119 antibody / N302_11251 antibody / N303_00957 antibody / N306_10912 antibody / N307_04959 antibody / N308_15583 antibody / N309_00745 antibody / N310_04033 antibody / N320_04271 antibody / N321_13006 antibody / N322_03220 antibody / N324_12113 antibody / N325_03852 antibody / N328_05560 antibody / N329_02128 antibody / N330_09548 antibody / N331_03630 antibody / N333_04464 antibody / N336_01613 antibody / N340_13462 antibody / PAL_GLEAN10024902 antibody / PANDA_005471 antibody / synaptic vesicle glycoprotein 2B antibody / synaptic vesicle protein 2C antibody / UY3_11456 antibody / Y1Q_024430 antibody / Y956_06893 antibody / Z169_10269 antibody
Function Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
Post-translational Modifications N-glycosylated.
Cellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Note=Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity).

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