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Anti-TIMP-1 antibody

[STJ96023] Download PDF Print Data Sheet
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Product name Anti-TIMP-1 antibody
Short Description Rabbit polyclonal to TIMP-1.
Description TIMP-1 is a protein encoded by the TIMP-1 gene which is approximately 23,2 kDa. TIMP-1 is involved in the GPCR pathway, phospholipase-C pathway, apoptotic pathways in synovial fibroblasts, ERK signalling and the CREB pathway. It functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signalling cascades via CD63 and ITGB1, it also acts as an inhibitor of MMPs which are groups of peptides involved in extracellular matrix degradation. TIMP-1 is secreted and is only active in the presence of disulphide bonds. It is ubiquitously expressed in numerous cells and tissues of the body. Mutations in the TIMP-1 gene may result in chronic venous leg ulcers and oral submucous fibrosis. STJ96023 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of TIMP-1 protein.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:10000
Specificity TIMP-1 Polyclonal Antibody detects endogenous levels of TIMP-1 protein.
Protein Name Metalloproteinase inhibitor 1
Erythroid-potentiating activity
EPA
Fibroblast collagenase inhibitor
Collagenase inhibitor
Tissue inhibitor of metalloproteinases 1
TIMP-1
Immunogen Synthesized peptide derived from human TIMP-1
Immunogen Region 30-110 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7076
Gene Symbol TIMP1
Molecular Weight 24 kDa
Database Links HGNC:11820
OMIM:305370
Alternative Names Anti-TIMP-1 antibody
Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Post-translational Modifications The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated.
Cellular Localization Secreted
Tissue Specificity Detected in rheumatoid synovial fluid (at protein level).
Swiss-Prot Key P01033_HUMAN
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