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Anti-Tom20 antibody

[STJ96061] Download PDF Print Data Sheet

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Product name Anti-Tom20 antibody
Short Description Rabbit Polyclonal to Tom20.
Description Tom20 is a protein encoded by the TOMM20 gene which is approximately 16,2 kDa. Tom20 is localised to the mitochondrion outer membrane and is involved in deubiquitination, metabolism of proteins, pink/parkin mediated mitophagy, and glucose / energy metabolism. It is a central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Tom20 is expressed in the nervous system, bone marrow, pancreas, eye and liver. Mutations in the TOMM20 gene result in Perry syndrome and infantile neuroaxonal dystrophy. STJ96061 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Tom20 protein.
Applications ELISA, WB
Dilution range WB 1:500-1:2000 / ELISA 1:40000 /
Specificity Tom20 Polyclonal Antibody detects endogenous levels of Tom20 protein.
Protein Name Mitochondrial import receptor subunit TOM20 homolog - TOMM20 - KIAA0016 - TOM20 - MOM19 - MAS20 - translocase of outer mitochondrial membrane 20
Immunogen Synthesized peptide derived from human Tom20
Immunogen Region 30-110 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 9804 (Human) / 67952 (Mouse) / 266601 (Rat)
Gene Symbol TOMM20
Molecular Weight 17 kDa
Database Links Human UniProt/Swiss-Prot:Q15388 Mouse UniPort/Swiss-Prot: Q9DCC8 Rat UniProt/Swiss-Port: Q62760 Human Entrez Gene: 9804 Mouse Entrez Gene: 67952 Rat Entrez Gene: Rn.2143
Alternative Names TOMM20 / translocase of outer mitochondrial membrane 20 / A306_05456 antibody / AS27_01502 antibody / AS28_13978 antibody / CB1_000713012 antibody / EH28_05936 antibody / GW7_10995 antibody / H920_04372 antibody / M91_12184 antibody / M959_14699 antibody / MAS20 antibody / MDA_GLEAN10022797 antibody / mitochondrial 20 kDa outer membrane protein antibody / mitochondrial 20 kDa outer membrane protein B antibody / Mitochondrial import receptor subunit TOM20 antibody / Mitochondrial import receptor subunit TOM20 homolog antibody / Mitochondrial import receptor subunit TOM20 like protein antibody / Mitochondrial import receptor subunit TOM20-like protein antibody / Mitochondrial outer membrane receptor TOM20 (MAS20P / S cervisiae homolog) acidic calcium-independent phospholipase A2 antibody / MOM19 antibody / N300_09790 antibody / N301_15235 antibody / N302_14480 antibody / N303_13408 antibody / N305_06225 antibody / N306_07700 antibody / N307_04612 antibody / N308_14152 antibody / N309_12764 antibody / N312_12484 antibody / N320_03351 antibody / N321_08476 antibody / N324_00985 antibody / N326_00647 antibody / N327_11547 antibody / N328_00279 antibody / N329_03499 antibody / N330_10877 antibody / N332_08659 antibody / N333_09199 antibody / N334_05747 antibody / N335_12248 antibody / N336_08284 antibody / N339_00557 antibody / N340_04702 antibody / N341_09443 antibody / outer mitochondrial membrane receptor rTOM20 antibody / outer mitochondrial membrane receptor Tom20 antibody / outer mitochondrial membrane receptor Tom20-B antibody / PAL_GLEAN10008164 antibody / putative import receptor subunit TOM20 like protein antibody / putative translocase of outer mitochondrial membrane 20 variant 3 antibody / tom20 antibody / tomm20b antibody / translocase of outer mitochondrial membrane 20 homolog antibody / translocase of outer mitochondrial membrane 20 homolog b antibody / translocase of outer mitochondrial membrane 20 homolog type II antibody / translocase of outer mitochondrial membrane 20 homolog (yeast) antibody / translocase of outer mitochondrial membrane 20-like antibody / translocase of outer mitochondrial membrane 20-like protein antibody / TREES_T100003920 antibody / UY3_15648 antibody / Y1Q_026724 antibody / Y956_02862 antibody / Z169_01114 antibody
Function Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
Post-translational Modifications Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Cellular Localization Mitochondrion outer membrane

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