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Anti-V-ATPase B1 antibody

[STJ96223] Download PDF Print Data Sheet

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Product name Anti-V-ATPase B1 antibody
Short Description Rabbit Polyclonal to V-ATPase B1.
Description V-ATPase B1 is a protein encoded by the ATP6V1B1 gene which is approximately 56,8 kDa. V-ATPase B1 is localised to the endomembrane system. It is involved in insulin receptor recycling, innate immune system, metabolism and mTOR signalling pathway. It mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation. V-ATPase B1 is expressed in the cochlea and endolymphatic sac. Mutations in the ATP6V1B1 gene may result in renal tubular acidosis with progressive nerve deafness. STJ96223 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of V-ATPase B1 protein.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:5000 /
Specificity V-ATPase B1 Polyclonal Antibody detects endogenous levels of V-ATPase B1 protein.
Protein Name V-type proton ATPase subunit B kidney isoform - ATP6V1B1 - VATB - RTA1B - Vma2 - VPP3 - ATP6B1 - ATPase H+ transporting V1 subunit B1
Immunogen Synthesized peptide derived from human V-ATPase B1
Immunogen Region 350-430 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 525 (Human) /
Gene Symbol ATP6V1B1
Molecular Weight 60 kDa
Database Links Human UniProt/Swiss-Prot:P15313 Human Entrez Gene: 525 Mouse Entrez Gene: 110935 Rat Entrez Gene: Rn.103610
Alternative Names ATP6V1B1 / ATPase H+ transporting V1 subunit B1 / A306_14036 antibody / AS27_06014 antibody / Atp6b1 antibody / ATPase / H+ transporting / lysosomal 56 /58kDa / V1 subunit B antibody / ATPase / H+ transporting / lysosomal 56 /58kDa / V1 subunit B1 antibody / ATPase / H+ transporting / lysosomal 56 /58kDa / V1 subunit B1 (Renal tubular acidosis with deafness) antibody / ATPase / H transporting / lysosomal V1 subunit B1 antibody / ATPase / H+ transporting / lysosomal V1 subunit B1 antibody / ATPase / H+ transporting / lysosomal (vacuolar proton pump) / beta 56 /58 kDa antibody / ATPase / H+ transporting / V1 subunit B antibody / ATPase / H+ transporting / V1 subunit B1 antibody / D630003L15 antibody / EGK_05426 antibody / endomembrane proton pump 58 kDa subunit antibody / GW7_04939 antibody / H920_17454 antibody / H+-ATPase beta 1 subunit antibody / H(+)-transporting two-sector ATPase / 58kD subunit antibody / hypothetical protein antibody / I79_021159 antibody / lysosomal 56 /58kDa antibody / N300_08991 antibody / N301_12388 antibody / N302_15425 antibody / N303_13543 antibody / N307_13999 antibody / N309_00909 antibody / N329_03319 antibody / PAL_GLEAN10021137 antibody / PANDA_002877 antibody / RTA1B antibody / TREES_T100006666 antibody / UY3_10982 antibody / vacuolar H+-ATPase antibody / vacuolar proton pump 3 antibody / vacuolar proton pump / subunit 3 antibody / vacuolar proton pump subunit B 1 antibody / VATB antibody / V-ATPase B1 subunit antibody / V-ATPase subunit B 1 antibody / Ventral anterior homeobox 2a antibody / VMA2 antibody / Vpp3 antibody / Vpp-3 antibody / V-type proton ATPase subunit B / brain isoform antibody / V-type proton ATPase subunit B / kidney isoform antibody / Y1Q_029668 antibody / Y956_14472 antibody
Function Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Cellular Localization Endomembrane system; Peripheral membrane protein. Note=Endomembrane.
Tissue Specificity Expressed in the cochlea and endolymphatic sac.
Sequence and Domain Family The PDZ-binding motif mediates interactions with SLC9A3R1 and SCL4A7.

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