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Anti-WAVE2 antibody

[STJ96263] Download PDF Print Data Sheet

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Product name Anti-WAVE2 antibody
Short Description Rabbit Polyclonal to WAVE2.
Description WAVE2 is a protein encoded by the WASF2 gene which is approximately 54,2 kDa. WAVE2 is localised to the cytoplasm and is involved in regulation of actin dynamics for phagocytic cup formation, innate immune system, signalling by Rho GTPases and RET signalling. It is a downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton and is expressed in all tissues. Mutations in the WASF2 gene may result in Wiskott-Aldrich syndrome and depression. STJ96263 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of WAVE2 protein.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:5000 /
Specificity WAVE2 Polyclonal Antibody detects endogenous levels of WAVE2 protein.
Protein Name Wiskott-Aldrich syndrome protein family member 2 - WASF2 - WAVE2 - SCAR2 - WAS protein family member 2
Immunogen Synthesized peptide derived from human WAVE2
Immunogen Region 110-190 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 10163 (Human) / 242687 (Mouse) /
Gene Symbol WASF2
Molecular Weight 55 kDa
Database Links Human UniProt/Swiss-Prot:Q9Y6W5 Mouse UniPort/Swiss-Prot: Q8BH43 Rat UniProt/Swiss-Port: Q5FWU0 Human Entrez Gene: 10163 Mouse Entrez Gene: 242687 Rat Entrez Gene: Rn.162111
Alternative Names WASF2 / WAS protein family member 2 / A306_13904 antibody / AS27_08866 antibody / AS28_01057 antibody / CB1_000129014 antibody / D4Ertd13e antibody / dJ393P12.2 antibody / GW7_08438 antibody / H920_00847 antibody / I79_019962 antibody / IMD2 antibody / M91_13429 antibody / N300_05816 antibody / N301_06069 antibody / N305_00622 antibody / N306_15619 antibody / N307_14751 antibody / N308_12896 antibody / N311_03487 antibody / N312_05742 antibody / N320_03714 antibody / N321_02044 antibody / N322_06806 antibody / N326_08194 antibody / N327_09595 antibody / N328_05282 antibody / N329_06930 antibody / N331_04271 antibody / N332_09097 antibody / N333_06789 antibody / N334_08748 antibody / N335_08344 antibody / N336_06453 antibody / N339_06773 antibody / N340_09098 antibody / PAL_GLEAN10015079 antibody / PANDA_001176 antibody / protein WAVE-2 antibody / putative Wiskott-Aldrich syndrome protein family member 4 antibody / SCAR2 antibody / suppressor of cyclic-AMP receptor (WASP-family) antibody / TREES_T100012092 antibody / UY3_11774 antibody / verprolin homology domain-containing protein 2 antibody / WASF4 antibody / WASP family protein member 2 antibody / WASP family protein member 4 antibody / WASP family Verprolin-homologous protein 2 antibody / WAS protein family / member 2 antibody / WAVE2 antibody / Wiskott-Aldrich syndrome protein family member 2 antibody / wiskott-Aldrich syndrome protein family member 2-like protein antibody / Y1Q_005597 antibody / Y956_14874 antibody
Function Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Cellular Localization Cytoplasm, cytoskeleton Cell projection, lamellipodium Note=At the interface between the lamellipodial actin meshwork and the membrane.
Tissue Specificity Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.
Sequence and Domain Family Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.

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