|Product name||Anti-beta actin antibody|
|Description||Mouse Monoclonal to β-actin.|
|Reactivity||Human, Rat, Mouse, Monkey, Dog, Chicken, Hamster, Rabbit|
|Dilution range||WB 1:2000-5000|
|Specificity||The antibody detects endogenous β-actin protein.|
|Purification||The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.|
|Note||For research use only.|
|Protein Name||Actin cytoplasmic 1|
|Formulation||Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.|
|Storage Instruction||Store at -20°C. Avoid repeated freeze/thaw cycles.|
|Database Links||Genecards: 60 Swiss-Prot: P60709 HGNC: 132 Entrez gene: 60|
ACTB / actin, beta / act-2 antibody, ACT-5 antibody, ACTA1 antibody, actba antibody, actin antibody, actin, alpha 1, skeletal muscle antibody, actin beta antibody, actin, beta, cytoplasmic antibody, Actin, cytoplasmic 1 antibody, Actin, cytoplasmic type 5 antibody, Actx antibody, Anapl_00512 antibody, AS27_12274 antibody, AS28_05902 antibody, A-X actin-like protein antibody, Bact antibody, Bact; actin antibody, B-actin antibody, beta actin antibody, Beta-actin antibody, beta actin1 antibody, Beta-actin A antibody, beta cytoskeletal actin antibody, BRWS1 antibody, cytoplasmic 1 antibody, cytoplasmic actin OlCA1 antibody, cytoplasmic beta actin antibody, cytoplasmic beta-actin antibody, cytoskeletal beta actin antibody, D623_10011024 antibody, gamma non-muscle actin antibody, GW7_16883 antibody, H920_13304 antibody, hypothetical protein antibody, M91_16383 antibody, M959_04960 antibody, MDA_GLEAN10021467 antibody, melanoma X-actin antibody, N300_09809 antibody, N301_15340 antibody, N302_11832 antibody, N303_00828 antibody, N305_14864 antibody, N306_14056 antibody, N307_07714 antibody, N308_12235 antibody, N309_01588 antibody, N312_00100 antibody, olCA1 antibody, PAL_GLEAN10018968 antibody, PANDA_004593 antibody, PS1TP5-binding protein 1 antibody, ps1tp5bp1 antibody, putative beta-actin antibody, TREES_T100021367 antibody, UY3_09776 antibody, Y1Q_025431 antibody, Y956_00599 antibody, Z169_07136 antibody
|Function||Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|
|Sequence and Domain Family||Belongs to the actin family.|
|Post-translational Modifications||ISGylated. / Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity). / Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. / (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding . The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners .|
|Cellular Localization||Cytoplasm > cytoskeleton|
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Review by Viva Biotech Ltd.
Review by Sitti, March 2017.