| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (160-240 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP2R5B |
| Gene ID: | 5526 |
| Uniprot ID: | 2A5B_HUMAN |
| Immunogen Region: | 160-240 aa |
| Specificity: | 2A5B Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 160-240 |
| Post Translational Modifications | Ubiquitinated by E3 CUL3-KLHL15 complex.this modification leads to proteasomal degradation. |
| Function | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta IsoformPp2a B Subunit Isoform B'-BetaPp2a B Subunit Isoform B56-BetaPp2a B Subunit Isoform Pr61-BetaPp2a B Subunit Isoform R5-Beta |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-381038Reactome: R-HSA-389513Reactome: R-HSA-432142Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6811558Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta Isoform antibodyAnti-Pp2a B Subunit Isoform B'-Beta antibodyAnti-Pp2a B Subunit Isoform B56-Beta antibodyAnti-Pp2a B Subunit Isoform Pr61-Beta antibodyAnti-Pp2a B Subunit Isoform R5-Beta antibodyAnti-PPP2R5B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance