Anti-A20 antibody

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Product name Anti-A20 antibody
Short Description Rabbit polyclonal against A20
Description Rabbit polyclonal to A20.
Applications ELISA, IF, WB
Dilution range WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:20000
Specificity A20 polyclonal antibody detects endogenous levels of A20 protein.
Protein Name Tumor Necrosis Factor Alpha-Induced Protein 3
Tnf Alpha-Induced Protein 3
Otu Domain-Containing Protein 7c
Putative Dna-Binding Protein A20
Zinc Finger Protein A20 [Cleaved Into-A20p50-A20p37]
Immunogen Synthesized peptide derived from human A20
Immunogen Region 290-370 aa, Internal
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7128
Gene Symbol TNFAIP3
Molecular Weight 90 kDa
Database Links HGNC:11896
OMIM:191163
Alternative Names Anti-Tumor Necrosis Factor Alpha-Induced Protein 3 antibody
Anti-Tnf Alpha-Induced Protein 3 antibody
Anti-Otu Domain-Containing Protein 7c antibody
Anti-Putative Dna-Binding Protein A20 antibody
Anti-Zinc Finger Protein A20 [Cleaved Into-A20p50-A20p37] antibody
Anti-TNFAIP3 OTUD7C antibody
Function Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways.affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF-or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG.the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin.polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'-and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.
Post-translational Modifications Proteolytically cleaved by MALT1 upon TCR stimulation; disrupts NF-kappa-B inhibitory function and results in increased IL-2 production. It is proposed that only a fraction of TNFAIP3 colocalized with TCR and CBM complex is cleaved, leaving the main TNFAIP3 pool intact.
Cellular Localization Cytoplasm
Nucleus
Lysosome
A20p50: Cytoplasm
Swiss-Prot Key TNAP3_HUMAN
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