Anti-A2M antibody

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Product name Anti-A2M antibody
Short Description Rabbit polyclonal against A2M
Description Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
Applications IF, WB
Dilution range WB 1:500 - 1:2000 IF 1:50 - 1:200
Protein Name Alpha-2-Macroglobulin
C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1155-1474 of human A2M (NP_000005. 2).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 2
Gene Symbol A2M
Molecular Weight Calculated: 163kDa. Observed: 160kDa
Alternative Names Anti-Alpha-2-Macroglobulin antibody
Anti-Alpha-2-M antibody
Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibody
Anti-A2M CPAMD5 FWP007 antibody
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Cellular Localization Secreted
Tissue Specificity Secreted in plasma.
Swiss-Prot Key A2MG_HUMAN
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