• Western blot analysis of extracts of various cell lines, using AADAC antibody (STJ112402) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-AADAC antibody (170-399) (STJ112402)

SKU:
STJ112402

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AADAC (170-399) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AADAC
Gene ID: 13
Uniprot ID: AAAD_HUMAN
Immunogen Region: 170-399
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 170-399 of human AADAC (NP_001077.2).
Immunogen Sequence: KKVLAKYGVNPERIGISGDS AGGNLAAAVTQQLLDDPDVK IKLKIQSLIYPALQPLDVDL PSYQENSNFLFLSKSLMVRF WSEYFTTDRSLEKAMLSRQH VPVESSHLFKFVNWSSLLPE RFIKGHVYNNPNYGSSELAK KYPGFLDVRAAPLLADDNKL RGLPLTYVITCQYDLLRDDG LMYVTRLRNTGVQVTHNHVE DGFHGAFSFLGLKISHRLIN QYIEWLKENL
Tissue Specificity Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.
Post Translational Modifications Glycosylation is required for enzyme activity.
Function Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
Protein Name Arylacetamide Deacetylase
Database Links Reactome: R-HSA-211945
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Microsome Membrane
Alternative Antibody Names Anti-Arylacetamide Deacetylase antibody
Anti-AADAC antibody
Anti-DAC antibody

Information sourced from Uniprot.org

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