Anti-ABCC1 antibody

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Product name Anti-ABCC1 antibody
Short Description Rabbit polyclonal against ABCC1
Description The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
Applications IHC, WB
Dilution range WB 1:500 - 1:1000 IHC 1:50 - 1:200
Protein Name Multidrug Resistance-Associated Protein 1
Atp-Binding Cassette Sub-Family C Member 1
Glutathione-S-Conjugate-Translocating Atpase Abcc1
Leukotriene C(4 Transporter
Ltc4 Transporter
Immunogen A synthetic peptide of human ABCC1
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 4363
Gene Symbol ABCC1
Molecular Weight Calculated: 151-172kDa. Observed: 172kDa
Alternative Names Anti-Multidrug Resistance-Associated Protein 1 antibody
Anti-Atp-Binding Cassette Sub-Family C Member 1 antibody
Anti-Glutathione-S-Conjugate-Translocating Atpase Abcc1 antibody
Anti-Leukotriene C(4 Transporter antibody
Anti-Ltc4 Transporter antibody
Anti-ABCC1 MRP MRP1 antibody
Function Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells.
Cellular Localization Cell Membrane
Multi-Pass Membrane Protein
Tissue Specificity Lung, testis and peripheral blood mononuclear cells.
Swiss-Prot Key MRP1_HUMAN
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