Anti-ABCC1 antibody

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Product name Anti-ABCC1 antibody
Short Description Rabbit polyclonal to ABCC1
Description The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
Applications IHC, WB
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:200
Protein Name Multidrug resistance-associated protein 1
ATP-binding cassette sub-family C member 1
Leukotriene C(4
LTC4 transporter
Immunogen A synthetic peptide of human ABCC1
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 4363
Gene Symbol ABCC1
Molecular Weight 171.591 kDa
Database Links HGNC:51
Alternative Names Multidrug resistance-associated protein 1 antibody
ATP-binding cassette sub-family C member 1 antibody
Leukotriene C (4 antibody
transporter antibody
LTC4 transporter antibody
MRP antibody
MRP1 antibody
Function Mediates export of organic anions and drugs from the cytoplasm, Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics, Confers resistance to anticancer drugs, Hydrolyzes ATP with low efficiency,
Cellular Localization Cell membrane
Tissue Specificity Lung, testis and peripheral blood mononuclear cells
Swiss-Prot Key P33527
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