• Western blot analysis of various lysates using ABCG4 Rabbit polyclonal antibody (STJ116806) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-ABCG4 antibody (270-370) (STJ116806)

SKU:
STJ116806

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ABCG4 (270-370) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCG4
Gene ID: 64137
Uniprot ID: ABCG4_HUMAN
Immunogen Region: 270-370
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 270-370 of human ABCG4 (NP_071452.2).
Immunogen Sequence: KLYILSQGQCIFKGVVTNLI PYLKGLGLHCPTYHNPADFI IEVASGEYGDLNPMLFRAVQ NGLCAMAEKKSSPEKNEVPA PCPPCPPEVDPIESHTFATS T
Tissue Specificity Expressed specifically in the brain and the eye.
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment. Induces apoptosis in various cells.
Protein Name Atp-Binding Cassette Sub-Family G Member 4
Database Links Reactome: R-HSA-1369062
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle Membrane
Endosome Membrane
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family G Member 4 antibody
Anti-ABCG4 antibody
Anti-WHITE2 antibody

Information sourced from Uniprot.org

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