Anti-ACADL antibody

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Product name Anti-ACADL antibody
Short Description Rabbit polyclonal against ACADL
Description The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia.
Applications IF, IHC, WB
Dilution range WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
Protein Name Long-Chain Specific Acyl-Coa Dehydrogenase-Mitochondrial
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 31-210 of human ACADL (NP_001599. 1).
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 33
Gene Symbol ACADL
Molecular Weight Calculated: 47kDa. Observed: 47kDa
Database Links Reactome: R-HSA-77285
Alternative Names Anti-Long-Chain Specific Acyl-Coa Dehydrogenase-Mitochondrial antibody
Anti-Lcad antibody
Anti-ACADL antibody
Function Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains.
Post-translational Modifications Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3.
Cellular Localization Mitochondrion Matrix
Swiss-Prot Key ACADL_HUMAN
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