Anti-ACADM Antibody

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Product name Anti-ACADM Antibody
Short Description Rabbit polyclonal against ACADM
Description This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications IF, IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Medium-chain specific acyl-CoA dehydrogenase
mitochondrial
MCAD
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACADM (NP_000007.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 34
Gene Symbol ACADM
Molecular Weight 46.588 kDa
Database Links HGNC:89
OMIM:201450
Reactome:R-HSA-1989781
Alternative Names Medium-chain specific acyl-CoA dehydrogenase
mitochondrial
MCAD
Function Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation, Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase),
Post-translational Modifications Acetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity , These sites are deacetylated by SIRT3,
Cellular Localization Mitochondrion matrix
Swiss-Prot Key P11310
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