| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADAMTS2 (1029-1213) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAMTS2 |
| Gene ID: |
9509 |
| Uniprot ID: |
ATS2_HUMAN |
| Immunogen Region: |
1029-1213 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1029-1213 of human ADAMTS2 (O95450). |
| Immunogen Sequence: |
PRNISDPSKKSYVVQWLSRP DPDSPIRKISSKGHCQGDKS IFCRMEVLSRYCSIPGYNKL CCKSCNLYNNLTNVEGRIEP PPGKHNDIDVFMPTLPVPTV AMEVRPSPSTPLEVPLNASS TNATEDHPETNAVDEPYKIH GLEDEVQPPNLIPRRPSPYE KTRNQRIQELIDEMRKKEML GKF |
| Tissue Specificity | Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2Adam-Ts 2Adam-Ts2Adamts-2Procollagen I N-ProteinasePc I-NpProcollagen I/Ii Amino Propeptide-Processing EnzymeProcollagen N-EndopeptidasePnpi |
| Database Links | Reactome: R-HSA-1650814Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2 antibodyAnti-Adam-Ts 2 antibodyAnti-Adam-Ts2 antibodyAnti-Adamts-2 antibodyAnti-Procollagen I N-Proteinase antibodyAnti-Pc I-Np antibodyAnti-Procollagen I/Ii Amino Propeptide-Processing Enzyme antibodyAnti-Procollagen N-Endopeptidase antibodyAnti-Pnpi antibodyAnti-ADAMTS2 antibodyAnti-PCINP antibodyAnti-PCPNI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
