Anti-AKTIP Antibody

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Product name Anti-AKTIP Antibody
Short Description Rabbit polyclonal against AKTIP
Description The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name AKT-interacting protein
Ft1
Fused toes protein homolog
Immunogen A synthetic peptide of human AKTIP
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 64400
Gene Symbol AKTIP
Molecular Weight 33.128 kDa
Database Links HGNC:16710
OMIM:608483
Alternative Names AKT-interacting protein
Ft1
Fused toes protein homolog
Function Component of the FTS/Hook/FHIP complex (FHF complex), The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex), Regulates apoptosis by enhancing phosphorylation and activation of AKT1, Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade,
Cellular Localization Cytoplasm
Swiss-Prot Key Q9H8T0
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