| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AOC3 (27-190) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AOC3 |
| Gene ID: |
8639 |
| Uniprot ID: |
AOC3_HUMAN |
| Immunogen Region: |
27-190 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-190 of human AOC3 (NP_003725.1). |
| Immunogen Sequence: |
GRGGDGGEPSQLPHCPSVSP SAQPWTHPGQSQLFADLSRE ELTAVMRFLTQRLGPGLVDA AQARPSDNCVFSVELQLPPK AAALAHLDRGSPPPAREALA IVFFGRQPQPNVSELVVGPL PHPSYMRDVTVERHGGPLPY HRRPVLFQEYLDIDQMIFNR ELPQ |
| Tissue Specificity | Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung. |
| Post Translational Modifications | Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. N- and O-glycosylated. |
| Function | Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. |
| Protein Name | Membrane Primary Amine OxidaseCopper Amine OxidaseHpaoSemicarbazide-Sensitive Amine OxidaseSsaoVascular Adhesion Protein 1Vap-1 |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Membrane Primary Amine Oxidase antibodyAnti-Copper Amine Oxidase antibodyAnti-Hpao antibodyAnti-Semicarbazide-Sensitive Amine Oxidase antibodyAnti-Ssao antibodyAnti-Vascular Adhesion Protein 1 antibodyAnti-Vap-1 antibodyAnti-AOC3 antibodyAnti-VAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
