Anti-ATF2 antibody

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Product name Anti-ATF2 antibody
Short Description Rabbit polyclonal against ATF2
Description This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene
Applications WB
Dilution range WB 1:200 - 1:500
Protein Name Cyclic Amp-Dependent Transcription Factor Atf-2
Camp-Dependent Transcription Factor Atf-2
Activating Transcription Factor 2
Cyclic Amp-Responsive Element-Binding Protein 2
Creb-2
Camp-Responsive Element-Binding Protein 2
Hb16
Histone Acetyltransferase Atf2
Camp Response Element-Binding Protein Cre-Bp1
Immunogen A synthetic peptide of human ATF2
Storage Instruction Store at 4°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, pH7.3.
Gene ID 1386
Gene Symbol ATF2
Molecular Weight Calculated: 13- 15kDa/23-24kDa/35-54kDa. Observed: 20kDa
Database Links Reactome: R-HSA-2151201
Alternative Names Anti-Cyclic Amp-Dependent Transcription Factor Atf-2 antibody
Anti-Camp-Dependent Transcription Factor Atf-2 antibody
Anti-Activating Transcription Factor 2 antibody
Anti-Cyclic Amp-Responsive Element-Binding Protein 2 antibody
Anti-Creb-2 antibody
Anti-Camp-Responsive Element-Binding Protein 2 antibody
Anti-Hb16 antibody
Anti-Histone Acetyltransferase Atf2 antibody
Anti-Camp Response Element-Binding Protein Cre-Bp1 antibody
Anti-ATF2 CREB2 CREBP1 antibody
Function Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Post-translational Modifications Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4. ATM-mediated phosphorylation at Ser-490 and Ser-498 stimulates its function in DNA damage response. Phosphorylation at Ser-62, Thr-73 and Ser-121 activates its transcriptional activity. Phosphorylation at Thr-69 or Thr-71 enhances its histone acetyltransferase (HAT) activity.
Cellular Localization Nucleus
Cytoplasm
Mitochondrion Outer Membrane
Shuttles Between The Cytoplasm And The Nucleus And Heterodimerization With Jun Is Essential For The Nuclear Localization
Localization To The Cytoplasm Is Observed Under Conditions Of Cellular Stress And In Disease States
Localizes At The Mitochondrial Outer Membrane In Response To Genotoxic Stress
Phosphorylation At Thr-52 Is Required For Its Nuclear Localization And Negatively Regulates Its Mitochondrial Localization
Co-Localizes With The Mrn Complex In The Ir-Induced Foci (Irif)
Tissue Specificity Ubiquitously expressed, with more abundant expression in the brain.
Swiss-Prot Key ATF2_HUMAN
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