Anti-BFSP2 antibody

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Product name Anti-BFSP2 antibody
Short Description Rabbit polyclonal against BFSP2
Description More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, the protein product of this gene (phakinin), and filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene have been associated with juvenile-onset, progressive cataracts and Dowling-Meara epidermolysis bullosa simplex.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name Phakinin
49 Kda Cytoskeletal Protein
Beaded Filament Structural Protein 2
Lens Fiber Cell Beaded Filament Protein Cp 47
Cp47
Lens Fiber Cell Beaded Filament Protein Cp 49
Cp49
Lens Intermediate Filament-Like Light
Lifl-L
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 116-415 of human BFSP2 (NP_003562. 1).
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 8419
Gene Symbol BFSP2
Molecular Weight Calculated: 45kDa. Observed: 46kDa
Alternative Names Anti-Phakinin antibody
Anti-49 Kda Cytoskeletal Protein antibody
Anti-Beaded Filament Structural Protein 2 antibody
Anti-Lens Fiber Cell Beaded Filament Protein Cp 47 antibody
Anti-Cp47 antibody
Anti-Lens Fiber Cell Beaded Filament Protein Cp 49 antibody
Anti-Cp49 antibody
Anti-Lens Intermediate Filament-Like Light antibody
Anti-Lifl-L antibody
Anti-BFSP2 antibody
Function Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
Cellular Localization Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytoskeleton
Cell Cortex
Expressed Primarily At The Plasma Membrane In Peripheral Lens Fiber Cells
However Also Localizes To The Cytoplasm In Mature Lens Fiber Cells
Tissue Specificity Lens.
Swiss-Prot Key BFSP2_HUMAN
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