Anti-BPIFA1 antibody

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Product name Anti-BPIFA1 antibody
Short Description Rabbit polyclonal against BPIFA1
Description This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Bpi Fold-Containing Family A Member 1
Lung-Specific Protein X
Nasopharyngeal Carcinoma-Related Protein
Palate Lung And Nasal Epithelium Clone Protein
Secretory Protein In Upper Respiratory Tracts
Short Plunc1
Splunc1
Tracheal Epithelium-Enriched Protein
Von Ebner Protein Hl
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-256 of human BPIFA1 (NP_057667. 1).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 51297
Gene Symbol BPIFA1
Molecular Weight Calculated: 25kDa/26kDa. Observed: 26kDa
Alternative Names Anti-Bpi Fold-Containing Family A Member 1 antibody
Anti-Lung-Specific Protein X antibody
Anti-Nasopharyngeal Carcinoma-Related Protein antibody
Anti-Palate Lung And Nasal Epithelium Clone Protein antibody
Anti-Secretory Protein In Upper Respiratory Tracts antibody
Anti-Short Plunc1 antibody
Anti-Splunc1 antibody
Anti-Tracheal Epithelium-Enriched Protein antibody
Anti-Von Ebner Protein Hl antibody
Anti-BPIFA1 LUNX NASG PLUNC SPLUNC1 SPURT UNQ787/PRO1606 antibody
Function Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P. aeruginosa and K. pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils.
Post-translational Modifications May be N-glycosylated.
Cellular Localization Secreted
Apical Side Of Airway Epithelial Cells
Detected In Airway Surface Liquid
Nasal Mucus And Sputum
Tissue Specificity Highly expressed in lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium (at protein level). Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues (at protein level). Also expressed in the eye where it is detected in lacrimal gland, eyelid, conjunctiva and cornea (at protein level). Specifically localizes to epithelial cell layers in cornea, eyelid (basal epithelium) and conjunctiva (at protein level). Detected within acinar cells
Swiss-Prot Key BPIA1_HUMAN
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