Anti-BPIFA1 Antibody

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Product name Anti-BPIFA1 Antibody
Short Description Rabbit polyclonal against BPIFA1
Description This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name BPI fold-containing family A member 1
Lung-specific protein X
Nasopharyngeal carcinoma-related protein
Palate lung and nasal epithelium clone protein
Secretory protein in upper respiratory tracts
Short PLUNC1
SPLUNC1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-256 of human BPIFA1 (NP_057667.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 51297
Gene Symbol BPIFA1
Molecular Weight 26.713 kDa
Database Links HGNC:15749
OMIM:607412
Reactome:R-HSA-6803157
Alternative Names BPI fold-containing family A member 1
Lung-specific protein X
Nasopharyngeal carcinoma-related protein
Palate lung and nasal epithelium clone protein
Secretory protein in upper respiratory tracts
Short PLUNC1
SPLUNC1
Function Plays a role in the innate immune responses of the upper airways, Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P,aeruginosa and K,pneumoniae, Binds bacterial lipopolysaccharide (LPS), Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus, Plays a role in the airway inflammatory response after exposure to irritants, May attract macrophages and neutrophils, May be associated with tumor progression,
Post-translational Modifications May be N-glycosylated,
Cellular Localization Secreted,
Tissue Specificity Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium, Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues, Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways, Also expressed in lung cancers and some other types of cancer
Swiss-Prot Key Q9NP55
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