| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BPIFA1 (20-256) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BPIFA1 |
| Gene ID: |
51297 |
| Uniprot ID: |
BPIA1_HUMAN |
| Immunogen Region: |
20-256 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-256 of human BPIFA1 (NP_057667.1). |
| Immunogen Sequence: |
QFGGLPVPLDQTLPLNVNPA LPLSPTGLAGSLTNALSNGL LSGGLLGILENLPLLDILKP GGGTSGGLLGGLLGKVTSVI PGLNNIIDIKVTDPQLLELG LVQSPDGHRLYVTIPLGIKL QVNTPLVGASLLRLAVKLDI TAEILAVRDKQERIHLVLGD CTHSPGSLQISLLDGLGPLP IQGLLDSLTGILNKVLPELV QGNVCPLVNEVLRGLDITLV HDIVNMLIHGLQFVIKV |
| Tissue Specificity | Highly expressed in lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium (at protein level). Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues (at protein level). Also expressed in the eye where it is detected in lacrimal gland, eyelid, conjunctiva and cornea (at protein level). Specifically localizes to epithelial cell layers in cornea, eyelid (basal epithelium) and conjunctiva (at protein level). Detected within acinar cells and ducts in the lacrimal and Meibomian glands (at protein level). In lung, shows highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer. |
| Post Translational Modifications | May be N-glycosylated. |
| Function | Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. |
| Protein Name | Bpi Fold-Containing Family A Member 1Lung-Specific Protein XNasopharyngeal Carcinoma-Related ProteinPalate Lung And Nasal Epithelium Clone ProteinSecretory Protein In Upper Respiratory TractsShort Plunc1Splunc1Tracheal Epithelium-Enriched ProteinVon Ebner Protein Hl |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedApical Side Of Airway Epithelial CellsDetected In Airway Surface LiquidNasal Mucus And Sputum |
| Alternative Antibody Names | Anti-Bpi Fold-Containing Family A Member 1 antibodyAnti-Lung-Specific Protein X antibodyAnti-Nasopharyngeal Carcinoma-Related Protein antibodyAnti-Palate Lung And Nasal Epithelium Clone Protein antibodyAnti-Secretory Protein In Upper Respiratory Tracts antibodyAnti-Short Plunc1 antibodyAnti-Splunc1 antibodyAnti-Tracheal Epithelium-Enriched Protein antibodyAnti-Von Ebner Protein Hl antibodyAnti-BPIFA1 antibodyAnti-LUNX antibodyAnti-NASG antibodyAnti-PLUNC antibodyAnti-SPLUNC1 antibodyAnti-SPURT antibodyAnti-UNQ787 antibodyAnti-PRO1606 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
