Anti-c-FLIP antibody

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Anti-c-FLIP antibody

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Product name Anti-c-FLIP antibody
Short Description Rabbit polyclonal against c-FLIP
Description Rabbit polyclonal to c-FLIP.
Applications ELISA, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Specificity c-FLIP Polyclonal Antibody detects endogenous levels of c-FLIP protein.
Protein Name CASP8 and FADD-like apoptosis regulator
Caspase homolog
CASH
Caspase-eight-related protein
Casper
Caspase-like apoptosis regulatory protein
CLARP
Cellular FLICE-like inhibitory protein
c-FLIP
FADD-like
Immunogen Synthesized peptide derived from human c-FLIP
Immunogen Region 150-230 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 8837
Gene Symbol CFLAR
Molecular Weight 55 kDa
Database Links HGNC:1876
OMIM:603599
Alternative Names CASP8 and FADD-like apoptosis regulator
Caspase homolog
CASH
Caspase-eight-related protein
Casper
Caspase-like apoptosis regulatory protein
CLARP
Cellular FLICE-like inhibitory protein
c-FLIP
FADD-like
Function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Post-translational Modifications Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
Tissue Specificity Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Sequence and Domain Family The caspase domain lacks the active site residues involved in catalysis.
Swiss-Prot Key O15519_HUMAN
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