| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CBX2 (62-211) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CBX2 |
| Gene ID: |
84733 |
| Uniprot ID: |
CBX2_HUMAN |
| Immunogen Region: |
62-211 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 62-211 of human CBX2 (NP_116036.1). |
| Immunogen Sequence: |
EHEKEVQNRKRGKRPRGRPR KLTAMSSCSRRSKLKVGGCA GYADPTSQHPLGVGGRQREG LGPSGRGWHFCQQSVPLLGK QEPPFFLSLSFCCQGPQPAE SSSPPLPGASCFSLSCTPLC WVAGSNCCRQALFPPRGSLG DGKEQEACVQ |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression. |
| Protein Name | Chromobox Protein Homolog 2 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724 |
| Cellular Localisation | NucleusChromosomeLocalized In Distinct Foci On Chromatin And In ChromocentersLocalizes To The Inactive X ChromosomeSeems To Be Recruited To H3k27me3H3k9ac And H3k3me2 Sites On Chromatin |
| Alternative Antibody Names | Anti-Chromobox Protein Homolog 2 antibodyAnti-CBX2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
