• Immunohistochemistry analysis of CC2D1A in paraffin-embedded rat kidney using CC2D1A Rabbit polyclonal antibody (STJ22924) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of CC2D1A in paraffin-embedded human esophageal cancer using CC2D1A Rabbit polyclonal antibody (STJ22924) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of various lysates using CC2D1A Rabbit polyclonal antibody (STJ22924) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-CC2D1A antibody (1-150) (STJ22924)

SKU:
STJ22924

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CC2D1A (1-150) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CC2D1A
Gene ID: 54862
Uniprot ID: C2D1A_HUMAN
Immunogen Region: 1-150
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CC2D1A (NP_060191.3).
Immunogen Sequence: MHKRKGPPGPPGRGAAAARQ LGLLVDLSPDGLMIPEDGAN DEELEAEFLALVGGQPPALE KLKGKGPLPMEAIEKMASLC MRDPDEDEEEGTDEDDLEAD DDLLAELNEVLGEEQKASET PPPVAQPKPEAPHPGLETTL QERLALYQTA
Post Translational Modifications Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21.
Function Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
Protein Name Coiled-Coil And C2 Domain-Containing Protein 1a
Akt Kinase-Interacting Protein 1
Five Prime Repressor Element Under Dual Repression-Binding Protein 1
Fre Under Dual Repression-Binding Protein 1
Freud-1
Putative Nf-Kappa-B-Activating Protein 023n
Cellular Localisation Cytoplasm
Nucleus
Cytoskeleton
Microtubule Organizing Center
Centrosome
Alternative Antibody Names Anti-Coiled-Coil And C2 Domain-Containing Protein 1a antibody
Anti-Akt Kinase-Interacting Protein 1 antibody
Anti-Five Prime Repressor Element Under Dual Repression-Binding Protein 1 antibody
Anti-Fre Under Dual Repression-Binding Protein 1 antibody
Anti-Freud-1 antibody
Anti-Putative Nf-Kappa-B-Activating Protein 023n antibody
Anti-CC2D1A antibody
Anti-AKI1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance