• Western blot analysis of extracts of various cell lines, using CCL4 antibody (STJ22936) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-CCL4 antibody (1-92) (STJ22936)

SKU:
STJ22936

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Host: Rabbit
Applications: WB
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CCL4 (1-92) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCL4
Gene ID: 388372/6351
Uniprot ID: CCL4_HUMAN
Immunogen Region: 1-92
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-92 of human CCL4 (NP_002975.1).
Immunogen Sequence: MKLCVTVLSLLMLVAAFCSP ALSAPMGSDPPTACCFSYTA RKLPRNFVVDYYETSSLCSQ PAVVFQTKRSKQVCADPSES WVQEYVYDLELN
Post Translational Modifications N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
Function Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Protein Name C-C Motif Chemokine 4
G-26 T-Lymphocyte-Secreted Protein
Hc21
Lymphocyte Activation Gene 1 Protein
Lag-1
Mip-1-Beta(1-69
Macrophage Inflammatory Protein 1-Beta
Mip-1-Beta
Pat 744
Protein H400
Sis-Gamma
Small-Inducible Cytokine A4
T-Cell Activation Protein 2
Act-2 Cleaved Into - Mip-1-Beta(3-69
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Secreted
Alternative Antibody Names Anti-C-C Motif Chemokine 4 antibody
Anti-G-26 T-Lymphocyte-Secreted Protein antibody
Anti-Hc21 antibody
Anti-Lymphocyte Activation Gene 1 Protein antibody
Anti-Lag-1 antibody
Anti-Mip-1-Beta(1-69 antibody
Anti-Macrophage Inflammatory Protein 1-Beta antibody
Anti-Mip-1-Beta antibody
Anti-Pat 744 antibody
Anti-Protein H400 antibody
Anti-Sis-Gamma antibody
Anti-Small-Inducible Cytokine A4 antibody
Anti-T-Cell Activation Protein 2 antibody
Anti-Act-2 Cleaved Into - Mip-1-Beta(3-69 antibody
Anti-CCL4 antibody
Anti-LAG1 antibody
Anti-MIP1B antibody
Anti-SCYA4 antibody

Information sourced from Uniprot.org

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