Anti-CCNK Antibody

[STJ112299] Download PDF Print Data Sheet

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Product name Anti-CCNK Antibody
Short Description Rabbit polyclonal against CCNK
Description The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Cyclin-K
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human CCNK (NP_001092872.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 8812
Gene Symbol CCNK
Molecular Weight 64.24 kDa
Database Links HGNC:1596
OMIM:603544
Reactome:R-HSA-112382
Alternative Names Cyclin-K
Function Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases, Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A),
Cellular Localization Nucleus
Tissue Specificity Ubiquitously expressed, Highest levels in testis
Swiss-Prot Key O75909
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