Anti-CCNK antibody

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Product name Anti-CCNK antibody
Short Description Rabbit polyclonal against CCNK
Description The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Cyclin-K
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human CCNK (NP_001092872. 1).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 8812
Gene Symbol CCNK
Molecular Weight Calculated: 40kDa/41kDa/64kDa/66kDa. Observed: 90kDa
Alternative Names Anti-Cyclin-K antibody
Anti-CCNK CPR4 antibody
Function Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
Cellular Localization Nucleus
Tissue Specificity Widely expressed. Highest levels in testis.
Swiss-Prot Key CCNK_HUMAN
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