| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Lysosome-associated membrane glycoprotein 1 (211-260 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LAMP1 |
| Gene ID: |
3916 |
| Uniprot ID: |
LAMP1_HUMAN |
| Immunogen Region: |
211-260 aa |
| Specificity: |
CD107a Polyclonal Antibody detects endogenous levels of CD107a protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human LAMP1 at the amino acid range 211-260 |
| Function | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. (Microbial infection) Acts as a receptor for Lassa virus glycoprotein. Promotes also fusion of the virus with host membrane in less acidic endosomes. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. |
| Protein Name | Lysosome-Associated Membrane Glycoprotein 1Lamp-1Lysosome-Associated Membrane Protein 1Cd107 Antigen-Like Family Member ACd Antigen Cd107a |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneLate Endosome MembraneCell MembraneCytolytic Granule MembraneThis Protein Shuttles Between LysosomesEndosomesAnd The Plasma MembraneColocalizes With Osbpl1a At The Late Endosome |
| Alternative Antibody Names | Anti-Lysosome-Associated Membrane Glycoprotein 1 antibodyAnti-Lamp-1 antibodyAnti-Lysosome-Associated Membrane Protein 1 antibodyAnti-Cd107 Antigen-Like Family Member A antibodyAnti-Cd Antigen Cd107a antibodyAnti-LAMP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
