Anti-CD161 antibody

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Product name Anti-CD161 antibody
Short Description Rabbit polyclonal against CD161
Description Rabbit polyclonal to CD161.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:20000
Specificity CD161 polyclonal antibody detects endogenous levels of CD161 protein.
Protein Name Killer Cell Lectin-Like Receptor Subfamily B Member 1
C-Type Lectin Domain Family 5 Member B
Hnkr-P1a
Nkr-P1a
Natural Killer Cell Surface Protein P1a
Cd Antigen Cd161
Immunogen Synthesized peptide derived from human CD161.
Immunogen Region 101-150 aa, Internal
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 3820
Gene Symbol KLRB1
Molecular Weight 40 25 kDa
Database Links HGNC:6373
OMIM:602890
Alternative Names Anti-Killer Cell Lectin-Like Receptor Subfamily B Member 1 antibody
Anti-C-Type Lectin Domain Family 5 Member B antibody
Anti-Hnkr-P1a antibody
Anti-Nkr-P1a antibody
Anti-Natural Killer Cell Surface Protein P1a antibody
Anti-Cd Antigen Cd161 antibody
Anti-KLRB1 CLEC5B NKRP1A antibody
Function Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1, 3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Post-translational Modifications N-glycosylated. Contains sialic acid residues.
Cellular Localization Membrane
Single-Pass Type Ii Membrane Protein
Tissue Specificity Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Swiss-Prot Key KLRB1_HUMAN
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