Anti-CD274 antibody

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Product name Anti-CD274 antibody
Short Description Rabbit monoclonal to CD274
Description Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.
Applications IHC
Dilution range 1:100 - 1:200
Protein Name Programmed cell death 1 ligand 1
PD-L1
PDCD1 ligand 1
Programmed death ligand 1
B7 homolog 1
B7-H1
CD antigen CD274
Immunogen Human PD-L1 protein.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IHC
Host Rabbit
Clonality Monoclonal
Reactivity Human
Conjugation Unconjugated
Formulation Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Gene ID 29126
Gene Symbol CD274
Molecular Weight 33.3 kDa
Database Links HGNC:17635
OMIM:605402
Reactome:R-HSA-389948
Alternative Names Programmed cell death 1 ligand 1
PD-L1
PDCD1 ligand 1
Programmed death ligand 1
B7 homolog 1
B7-H1
CD antigen CD274
Function Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner, Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
Cellular Localization Cell membrane
Tissue Specificity Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Swiss-Prot Key Q9NZQ7
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