| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLCN2 (550-770) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCN2 |
| Gene ID: |
1181 |
| Uniprot ID: |
CLCN2_HUMAN |
| Immunogen Region: |
550-770 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 550-770 of human CLCN2 (NP_001164560.1). |
| Immunogen Sequence: |
PSLYDSIIRIKKLPYLPELG WGRHQQYRVRVEDIMVRDVP HVALSCTFRDLRLALHRTKG RMLALVESPESMILLGSIER SQVVALLGAQLSPARRRQHM QERRATQTSPLSDQEGPPTP EASVCFQVNTEDSAFPAARG ETHKPLKPALKRGPSVTRNL GESPTGSAESAGIALRSLFC GSPPPEAASEKLESCEKRKL KRVRISLASDADLEGEMSPE E |
| Tissue Specificity | Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells. Expressed in the adrenal gland, predominantly in the zona glomerulosa. |
| Post Translational Modifications | Phosphorylated. Activated by dephosphorylation. |
| Function | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis. |
| Protein Name | Chloride Channel Protein 2Clc-2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Chloride Channel Protein 2 antibodyAnti-Clc-2 antibodyAnti-CLCN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
