| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLEC5A (29-188) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLEC5A |
| Gene ID: |
23601 |
| Uniprot ID: |
CLC5A_HUMAN |
| Immunogen Region: |
29-188 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 29-188 of human CLEC5A (NP_037384.1). |
| Immunogen Sequence: |
QIFNKSNDGFTTTRSYGTVS QIFGSSSPSPNGFITTRSYG TVCPKDWEFYQARCFFLSTS ESSWNESRDFCKGKGSTLAI VNTPEKLKFLQDITDAEKYF IGLIYHREEKRWRWINNSVF NGNVTNQNQNFNCATIGLTK TFDAASCDISYRRICEKNAK |
| Tissue Specificity | Highly expressed in bone marrow with lower levels in synovium, lung and bronchus. Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells. |
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release. |
| Protein Name | C-Type Lectin Domain Family 5 Member AC-Type Lectin Superfamily Member 5Myeloid Dap12-Associating Lectin 1Mdl-1 |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 5 Member A antibodyAnti-C-Type Lectin Superfamily Member 5 antibodyAnti-Myeloid Dap12-Associating Lectin 1 antibodyAnti-Mdl-1 antibodyAnti-CLEC5A antibodyAnti-CLECSF5 antibodyAnti-MDL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
