Anti-CMTM6 antibody

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Product name Anti-CMTM6 antibody
Short Description Rabbit polyclonal against CMTM6
Description Rabbit polyclonal to CMTM6.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC-p 1:100-1:300
ELISA 1:20000
Specificity CMTM6 polyclonal antibody detects endogenous levels of CMTM6 protein.
Protein Name Cklf-Like Marvel Transmembrane Domain-Containing Protein 6
Chemokine-Like Factor Superfamily Member 6
Immunogen Synthesized peptide derived from human CMTM6.
Immunogen Region 131-180 aa, C-terminal
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 54918
Gene Symbol CMTM6
Molecular Weight 20 kDa
Database Links HGNC:19177
OMIM:607889
Alternative Names Anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 antibody
Anti-Chemokine-Like Factor Superfamily Member 6 antibody
Anti-CMTM6 CKLFSF6 antibody
Function Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
Cellular Localization Cell Membrane
Multi-Pass Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Co-Localizes With Pd-L1/Cd274 In The Plasma Membrane And In Recycling Endosomes
Tissue Specificity Expressed in the leukocytes, placenta and testis.
Swiss-Prot Key CKLF6_HUMAN
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