| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CNOT7 (90-160) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CNOT7 |
| Gene ID: |
29883 |
| Uniprot ID: |
CNOT7_HUMAN |
| Immunogen Region: |
90-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-160 of human CNOT7 (NP_037486.2). |
| Immunogen Sequence: |
PGTSTWQFNFKFNLTEDMYA QDSIELLTTSGIQFKKHEEE GIETQYFAELLMTSGVVLCE GVKWLSFHSGY |
| Function | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 7Btg1-Binding Factor 1Ccr4-Associated Factor 1Caf-1Caf1a |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115 |
| Cellular Localisation | NucleusCytoplasmP-BodyCytoplasmic Ribonucleoprotein GranuleNanos2 Promotes Its Localization To P-BodyRecruited To Cytoplasmic Ribonucleoprotein Membraneless Compartments By Caprin1Promoting Deadenylation Of Mrnas |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 7 antibodyAnti-Btg1-Binding Factor 1 antibodyAnti-Ccr4-Associated Factor 1 antibodyAnti-Caf-1 antibodyAnti-Caf1a antibodyAnti-CNOT7 antibodyAnti-CAF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
