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Anti-COL13A1 antibody

[STJ92376] Download PDF Print Data Sheet
Anti-COL13A1 antibody

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Product name Anti-COL13A1 antibody
Description Rabbit polyclonal to COL13A1.
Applications ELISA, IF
Dilution range IF 1:200-1:1000
ELISA 1:20000
Specificity COL13A1 Polyclonal Antibody detects endogenous levels of COL13A1 protein.
Protein Name Collagen alpha-1
XIII chain
COLXIIIA1
Immunogen Synthesized peptide derived from human COL13A1
Immunogen Region 610-690 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 1305
Gene Symbol COL13A1
Molecular Weight 70 kDa
Database Links HGNC:2190
OMIM:120350
Alternative Names Collagen alpha-1 antibody
XIII chain antibody
COLXIIIA1 antibody
Function Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering .
Cellular Localization Cell membrane Cell junction, synapse, postsynaptic cell membrane
Tissue Specificity Widely expressed in both fetal and adult ocular tissues (at protein level). In the eye, expression is accentuated in the ciliary muscle, optic nerve and the neural retina. In early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries and to cells of the cytotrophoblastic columns. Also detected in large decidual cells of the decidual membrane and to stromal cells of the gestational endometrium, but not in the epithelial cells in the endome
Swiss-Prot Key Q5TAT6_HUMAN
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Logan CV, Cossins J, Cruz PMR, et al. Congenital Myasthenic Syndrome Type 19 Is Caused by Mutations in COL13A1, Encoding the Atypical Non-fibrillar Collagen Type XIII a1 Chain. The American Journal of Human Genetics. 2015. 97, 878–885. doi.org/10.1016/j.ajhg

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