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Anti-COL17A1 antibody

[STJ92379] Download PDF Print Data Sheet
Anti-COL17A1 antibody
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Product name Anti-COL17A1 antibody
Description Rabbit polyclonal to COL17A1.
Applications ELISA, IHC
Dilution range IHC 1:100-1:300
ELISA 1:40000
Specificity COL17A1 Polyclonal Antibody detects endogenous levels of COL17A1 protein.
Protein Name Collagen alpha-1
XVII chain
180 kDa bullous pemphigoid antigen 2
Bullous pemphigoid antigen 2
120 kDa linear IgA disease antigen
120 kDa linear IgA dermatosis antigen
Linear IgA disease antigen 1
LAD-1
97 kDa linear IgA disease antigen
97 kDa linear IgA bullous dermatosis antigen
97 kDa LAD antigen
97-LAD
Linear IgA bullous disease antigen of 97 kDa
LABD97
Immunogen Synthesized peptide derived from human COL17A1
Immunogen Region 1-80 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Expected Application IHC,ELISA
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 1308
Gene Symbol COL17A1
Molecular Weight 150.419 kDa
Database Links HGNC:2194
OMIM:113811
Alternative Names Collagen alpha-1 antibody
XVII chain antibody
180 kDa bullous pemphigoid antigen 2 antibody
Bullous pemphigoid antigen 2 antibody
120 kDa linear IgA disease antigen antibody
120 kDa linear IgA dermatosis antigen antibody
Linear IgA disease antigen 1 antibody
LAD-1 antibody
97 kDa linear IgA disease antigen antibody
97 kDa linear IgA bullous dermatosis antigen antibody
97 kDa LAD antigen antibody
97-LAD antibody
Linear IgA bullous disease antigen of 97 kDa antibody
LABD97 antibody
BP180 antibody
BPAG2 antibody
Function May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
Post-translational Modifications The intracellular/endo domain is disulfide-linked.; Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.; The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-544.
Cellular Localization Cell junction, hemidesmosome. Membrane. Single-pass type II membrane protein. Localized along the plasma membrane of the hemidesmosome.. 120 kDa linear IgA disease antigen: Secreted, extracellular space, extracellular matrix, basement membrane. Exclusively localized to anchoring filaments. Localized to the epidermal side of split skin.. 97 kDa linear IgA disease antigen: Secreted, extracellular space, extracellular matrix, basement membrane. Localized in the lamina lucida beneath the hemidesmosomes.
Tissue Specificity Detected in skin . In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells (at protein level) . Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves.
Swiss-Prot Key Q9UMD9_HUMAN
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