Anti-COX4I1 Antibody

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Product name Anti-COX4I1 Antibody
Short Description Rabbit polyclonal against COX4I1
Description Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications FC, IF, IHC, IP, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20 - 1:50
IP 1:20 - 1:50
FC 1:20 - 1:50
Protein Name Cytochrome c oxidase subunit 4 isoform 1
mitochondrial
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
COX IV-1
Immunogen Recombinant protein of human COX4I1
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF IP FC
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 1327
Gene Symbol COX4I1
Molecular Weight 19.577 kDa
Database Links HGNC:2265
OMIM:123864
Reactome:R-HSA-5628897
Alternative Names Cytochrome c oxidase subunit 4 isoform 1
mitochondrial
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
COX IV-1
Function This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
Cellular Localization Mitochondrion inner membrane
Tissue Specificity Ubiquitous
Swiss-Prot Key P13073
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