Anti-COX7A2L Antibody

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Product name Anti-COX7A2L Antibody
Short Description Rabbit polyclonal against COX7A2L
Description Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Cytochrome c oxidase subunit 7A-related protein
mitochondrial
COX7a-related protein
Cytochrome c oxidase subunit VIIa-related protein
EB1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human COX7A2L (NP_004709.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 9167
Gene Symbol COX7A2L
Molecular Weight 12.615 kDa
Database Links HGNC:2289
OMIM:605771
Reactome:R-HSA-5628897
Alternative Names Cytochrome c oxidase subunit 7A-related protein
mitochondrial
COX7a-related protein
Cytochrome c oxidase subunit VIIa-related protein
EB1
Function Involved in the regulation of oxidative phosphorylation and energy metabolism , Necessary for the assembly of mitochondrial respiratory supercomplex ,
Cellular Localization Mitochondrion inner membrane
Swiss-Prot Key O14548
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Sara Cogliati, Enrique Calvo, Marta Loureiro, Adela M. Guaras, Rocio Nieto-Arellano, Carolina Garcia-Poyatos, Iakes Ezkurdia, Nadia Mercader, Jesús Vázquez & José Antonio Enriquez. "Mechanism of super-assembly of respiratory complexes III and IV". Nature 539, 579–582 (24 November 2016) doi:10.1038/nature20157 

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