Anti-CRNN antibody

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Product name Anti-CRNN antibody
Short Description Rabbit polyclonal against CRNN
Description This gene encodes a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Cornulin
53 Kda Putative Calcium-Binding Protein
53 Kda Squamous Epithelial-Induced Stress Protein
58 Kda Heat Shock Protein
Squamous Epithelial Heat Shock Protein 53
Tumor-Related Protein
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human CRNN (NP_057274. 1).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 49860
Gene Symbol CRNN
Molecular Weight Calculated: 53kDa. Observed: 60kDa
Alternative Names Anti-Cornulin antibody
Anti-53 Kda Putative Calcium-Binding Protein antibody
Anti-53 Kda Squamous Epithelial-Induced Stress Protein antibody
Anti-58 Kda Heat Shock Protein antibody
Anti-Squamous Epithelial Heat Shock Protein 53 antibody
Anti-Tumor-Related Protein antibody
Anti-CRNN C1orf10 DRC1 PDRC1 SEP53 antibody
Function Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways.
Cellular Localization Cytoplasm
Does Not Colocalize With Tgm1
Tissue Specificity Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels i
Swiss-Prot Key CRNN_HUMAN
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