• Western blot analysis of extracts of HepG2 cells, using CRNN antibody (STJ111406) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-CRNN antibody (396-495) (STJ111406)

SKU:
STJ111406

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CRNN (396-495) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRNN
Gene ID: 49860
Uniprot ID: CRNN_HUMAN
Immunogen Region: 396-495
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human CRNN (NP_057274.1).
Immunogen Sequence: GETVPGGQAQTGASTESGRQ EWSSTHPRRCVTEGQGDRQP TVVGEEWVDDHSRETVILRL DQGNLHTSVSSAQGQDAAQS EEKRGITARELYSYLRSTKP
Tissue Specificity Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR).
Function Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways.
Protein Name Cornulin
53 Kda Putative Calcium-Binding Protein
53 Kda Squamous Epithelial-Induced Stress Protein
58 Kda Heat Shock Protein
Squamous Epithelial Heat Shock Protein 53
Tumor-Related Protein
Cellular Localisation Cytoplasm
Does Not Colocalize With Tgm1
Alternative Antibody Names Anti-Cornulin antibody
Anti-53 Kda Putative Calcium-Binding Protein antibody
Anti-53 Kda Squamous Epithelial-Induced Stress Protein antibody
Anti-58 Kda Heat Shock Protein antibody
Anti-Squamous Epithelial Heat Shock Protein 53 antibody
Anti-Tumor-Related Protein antibody
Anti-CRNN antibody
Anti-C1orf10 antibody
Anti-DRC1 antibody
Anti-PDRC1 antibody
Anti-SEP53 antibody

Information sourced from Uniprot.org

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