Anti-CRNN Antibody

[STJ111406] Download PDF Print Data Sheet

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Product name Anti-CRNN Antibody
Short Description Rabbit polyclonal against CRNN
Description This gene encodes a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Cornulin
53 kDa putative calcium-binding protein
53 kDa squamous epithelial-induced stress protein
58 kDa heat shock protein
Squamous epithelial heat shock protein 53
Tumor-related protein
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human CRNN (NP_057274.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 49860
Gene Symbol CRNN
Molecular Weight 53.533 kDa
Database Links HGNC:1230
OMIM:611312
Alternative Names Cornulin
53 kDa putative calcium-binding protein
53 kDa squamous epithelial-induced stress protein
58 kDa heat shock protein
Squamous epithelial heat shock protein 53
Tumor-related protein
Function Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium, When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest,
Cellular Localization Cytoplasm,
Tissue Specificity Squamous epithelia cell-specific, Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level), Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx, Expressed in the fetal bladder and scalp skin, Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and
Swiss-Prot Key Q9UBG3
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