• Immunofluorescence analysis of PC-12 cells using CTNNA2 Rabbit polyclonal antibody (STJ117464) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of Neuro-2a cells using CTNNA2 Rabbit polyclonal antibody (STJ117464) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Immunohistochemistry analysis of paraffin-embedded mouse spinal cord using CTNNA2 antibody (STJ117464) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded mouse liver using CTNNA2 antibody (STJ117464) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded rat liver using CTNNA2 antibody (STJ117464) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of extracts of various cell lines, using CTNNA2 antibody (STJ117464) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-CTNNA2 antibody (167-290) (STJ117464)

SKU:
STJ117464

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CTNNA2 (167-290) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CTNNA2
Gene ID: 1496
Uniprot ID: CTNA2_HUMAN
Immunogen Region: 167-290
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 167-290 of human CTNNA2 (NP_001269526.1).
Immunogen Sequence: TNEQDLANRFKEFGKEMVKL NYVAARRQQELKDPHCRDEM AAARGALKKNATMLYTASQA FLRHPDVAATRANRDYVFKQ VQEAIAGISNAAQATSPTDE AKGHTGIGELAAALNEFDNK IILD
Tissue Specificity Expressed in neural tissues, with strongest expression in fetal and adult brain. Expressed in the developing cortical plate and marginal zone of 20-week-old human fetal brain.
Function May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
Protein Name Catenin Alpha-2
Alpha N-Catenin
Alpha-Catenin-Related Protein
Database Links Reactome: R-HSA-525793
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytoskeleton
Cell Junction
Adherens Junction
Cell Projection
Axon
Nucleus
Alternative Antibody Names Anti-Catenin Alpha-2 antibody
Anti-Alpha N-Catenin antibody
Anti-Alpha-Catenin-Related Protein antibody
Anti-CTNNA2 antibody
Anti-CAPR antibody

Information sourced from Uniprot.org

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