• Western blot analysis of various lysates using CWC22 Rabbit polyclonal antibody (STJ115082) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-CWC22 antibody (639-908) (STJ115082)

SKU:
STJ115082

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CWC22 (639-908) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CWC22
Gene ID: 57703
Uniprot ID: CWC22_HUMAN
Immunogen Region: 639-908
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 639-908 of human CWC22 (NP_065994.1).
Immunogen Sequence: LTDELREHLKNTPKVIVAQK PDVEQNKSSPSSSSSASSSS ESDSSDSDSDSSDSSSESSS EESDSSSISSHSSASANDVR KKGHGKTRSKEVDKLIRNQQ TNDRKQKERRQEHGHQETRT ERERRSEKHRDQNSSGSNWR DPITKYTSDKDVPSERNNYS RVANDRDQEMHIDLENKHGD PKKKRGERRNSFSENEKHTH RIKDSENFRRKDRSKSKEMN RKHSGSRSDEDRYQNGAER
Function Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
Protein Name Pre-Mrna-Splicing Factor Cwc22 Homolog
Nucampholin Homolog
Fsapb
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleus Speckle
Concentrates Around Speckles
Which Are Sites Of Pre-Mrna Synthesis And Processing
Where It Colocalizes With Ejc Core Proteins
Alternative Antibody Names Anti-Pre-Mrna-Splicing Factor Cwc22 Homolog antibody
Anti-Nucampholin Homolog antibody
Anti-Fsapb antibody
Anti-CWC22 antibody
Anti-KIAA1604 antibody
Anti-NCM antibody

Information sourced from Uniprot.org

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