Anti-Cyclophilin F antibody

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Product name Anti-Cyclophilin F antibody
Short Description Rabbit polyclonal against Cyclophilin F
Description Rabbit polyclonal to Cyclophilin F.
Applications ELISA, IF, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Specificity Cyclophilin F Polyclonal Antibody detects endogenous levels of Cyclophilin F protein.
Protein Name Peptidyl-prolyl cis-trans isomerase F, mitochondrial
PPIase F
Cyclophilin D
CyP-D
CypD
Cyclophilin F
Mitochondrial cyclophilin
CyP-M
Rotamase F
Immunogen Synthesized peptide derived from human Cyclophilin F
Immunogen Region 60-140 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 10105
Gene Symbol PPIF
Molecular Weight 22 kDa
Database Links HGNC:9259
OMIM:604486
Alternative Names Peptidyl-prolyl cis-trans isomerase F, mitochondrial
PPIase F
Cyclophilin D
CyP-D
CypD
Cyclophilin F
Mitochondrial cyclophilin
CyP-M
Rotamase F
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Post-translational Modifications Deacteylated at Lys-167 by SIRT3.
Cellular Localization Mitochondrion matrix
Swiss-Prot Key P30405_HUMAN
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