Anti-DCSTAMP antibody

[STJ116837] Download PDF Print Data Sheet

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Product name Anti-DCSTAMP antibody
Short Description Rabbit polyclonal against DCSTAMP
Description This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name Dendritic Cell-Specific Transmembrane Protein
Dc-Stamp
Hdc-Stamp
Dendrocyte-Expressed Seven Transmembrane Protein
Il-Four-Induced Protein
Find
Transmembrane 7 Superfamily Member 4
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 401-470 of human DCSTAMP (NP_110415. 1).
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 81501
Gene Symbol DCSTAMP
Molecular Weight Calculated: 31kDa/53kDa. Observed: 53kDa
Database Links Reactome: R-HSA-8874211
Alternative Names Anti-Dendritic Cell-Specific Transmembrane Protein antibody
Anti-Dc-Stamp antibody
Anti-Hdc-Stamp antibody
Anti-Dendrocyte-Expressed Seven Transmembrane Protein antibody
Anti-Il-Four-Induced Protein antibody
Anti-Find antibody
Anti-Transmembrane 7 Superfamily Member 4 antibody
Anti-DCSTAMP TM7SF4 antibody
Function Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
Post-translational Modifications Glycosylated.
Cellular Localization Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Endosome
Localizes To The Cell Surface In Osteoclasts And Undifferentiated Monocytes
Intracellular Internalized Dcstamp Is Detected In A Fraction Of Rankl-Induced Osteoclast Precursor
Colocalizes With Os9 In The Endoplasmic Reticulum (Er) Of Immature Dendritic Cell (Dc)
Translocates From The Endoplasmic Reticulum To The Intermediate/Golgi Compartment Upon Maturation Of Dc In A Os9-Dependent Manner
Colocalizes With Lamp1 In Endosomes
Tissue Specificity Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs. Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes.
Swiss-Prot Key DCSTP_HUMAN
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