| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DCSTAMP (401-470) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DCSTAMP |
| Gene ID: |
81501 |
| Uniprot ID: |
DCSTP_HUMAN |
| Immunogen Region: |
401-470 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 401-470 of human DCSTAMP (NP_110415.1). |
| Immunogen Sequence: |
KILVSASFYPSVERKRIQYL HAKLLKKRSKQPLGEVKRRL SLYLTKIHFWLPVLKMIRKK QMDMASADKS |
| Tissue Specificity | Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs. Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes. |
| Post Translational Modifications | Glycosylated. |
| Function | Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. |
| Protein Name | Dendritic Cell-Specific Transmembrane ProteinDc-StampHdc-StampDendrocyte-Expressed Seven Transmembrane ProteinIl-Four-Induced ProteinFindTransmembrane 7 Superfamily Member 4 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneEndosomeLocalizes To The Cell Surface In Osteoclasts And Undifferentiated MonocytesIntracellular Internalized Dcstamp Is Detected In A Fraction Of Rankl-Induced Osteoclast PrecursorColocalizes With Os9 In The Endoplasmic Reticulum (Er) Of Immature Dendritic Cell (Dc)Translocates From The Endoplasmic Reticulum To The Intermediate/Golgi Compartment Upon Maturation Of Dc In A Os9-Dependent MannerColocalizes With Lamp1 In Endosomes |
| Alternative Antibody Names | Anti-Dendritic Cell-Specific Transmembrane Protein antibodyAnti-Dc-Stamp antibodyAnti-Hdc-Stamp antibodyAnti-Dendrocyte-Expressed Seven Transmembrane Protein antibodyAnti-Il-Four-Induced Protein antibodyAnti-Find antibodyAnti-Transmembrane 7 Superfamily Member 4 antibodyAnti-DCSTAMP antibodyAnti-TM7SF4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
