Anti-DCSTAMP Antibody

[STJ116837] Download PDF Print Data Sheet

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Product name Anti-DCSTAMP Antibody
Short Description Rabbit polyclonal against DCSTAMP
Description This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Dendritic cell-specific transmembrane protein
DC-STAMP
hDC-STAMP
Dendrocyte-expressed seven transmembrane protein
IL-four-induced protein
FIND
Transmembrane 7 superfamily member 4
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 401-470 of human DCSTAMP (NP_110415.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 81501
Gene Symbol DCSTAMP
Molecular Weight 53.393 kDa
Database Links HGNC:18549
OMIM:605933
Reactome:R-HSA-8874211
Alternative Names Dendritic cell-specific transmembrane protein
DC-STAMP
hDC-STAMP
Dendrocyte-expressed seven transmembrane protein
IL-four-induced protein
FIND
Transmembrane 7 superfamily member 4
Function Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis, Plays a role in TNFSF11-mediated osteoclastogenesis, Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs), Participates in osteoclast bone resorption, Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors, Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage, Inhibits the development of neutrophilic granulocytes, Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity, Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions
Post-translational Modifications Glycosylated,
Cellular Localization Cell membrane,
Tissue Specificity Preferentially expressed by dendritic cells (DCs), Detected in both immature and mature DCs, Highly expressed in lymph nodes, lung, kidney and liver, Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells, Not expressed in freshly isolated monocytes
Swiss-Prot Key Q9H295
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