| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DDR1 (290-420) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DDR1 |
| Gene ID: |
780 |
| Uniprot ID: |
DDR1_HUMAN |
| Immunogen Region: |
290-420 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 290-420 of human DDR1 (NP_054700.2). |
| Immunogen Sequence: |
MHTLGARLPGGVECRFRRGP AMAWEGEPMRHNLGGNLGDP RARAVSVPLGGRVARFLQCR FLFAGPWLLFSEISFISDVV NNSSPALGGTFPPAPWWPPG PPPTNFSSLELEPRGQQPVA KAEGSPTAILI |
| Tissue Specificity | Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin. |
| Post Translational Modifications | Autophosphorylated in response to fibrillar collagen binding. Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen. |
| Function | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. |
| Protein Name | Epithelial Discoidin Domain-Containing Receptor 1Epithelial Discoidin Domain Receptor 1Cd167 Antigen-Like Family Member ACell Adhesion KinaseDiscoidin Receptor Tyrosine KinaseHgk2Mammary Carcinoma Kinase 10Mck-10Protein-Tyrosine Kinase 3aProtein-Tyrosine Kinase Rtk-6Trk ETyrosine Kinase DdrTyrosine-Protein Kinase CakCd Antigen Cd167a |
| Database Links | Reactome: R-HSA-3000171 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneIsoform 3: SecretedIsoform 4: Cell Membrane |
| Alternative Antibody Names | Anti-Epithelial Discoidin Domain-Containing Receptor 1 antibodyAnti-Epithelial Discoidin Domain Receptor 1 antibodyAnti-Cd167 Antigen-Like Family Member A antibodyAnti-Cell Adhesion Kinase antibodyAnti-Discoidin Receptor Tyrosine Kinase antibodyAnti-Hgk2 antibodyAnti-Mammary Carcinoma Kinase 10 antibodyAnti-Mck-10 antibodyAnti-Protein-Tyrosine Kinase 3a antibodyAnti-Protein-Tyrosine Kinase Rtk-6 antibodyAnti-Trk E antibodyAnti-Tyrosine Kinase Ddr antibodyAnti-Tyrosine-Protein Kinase Cak antibodyAnti-Cd Antigen Cd167a antibodyAnti-DDR1 antibodyAnti-CAK antibodyAnti-EDDR1 antibodyAnti-NEP antibodyAnti-NTRK4 antibodyAnti-PTK3A antibodyAnti-RTK6 antibodyAnti-TRKE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
