| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DDR2 (290-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DDR2 |
| Gene ID: |
4921 |
| Uniprot ID: |
DDR2_HUMAN |
| Immunogen Region: |
290-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 290-400 of human DDR2 (NP_001014796.1). |
| Immunogen Sequence: |
NMFAKGVKIFKEVQCYFRSE ASEWEPNAISFPLVLDDVNP SARFVTVPLHHRMASAIKCQ YHFADTWMMFSEITFQSDAA MYNNSEALPTSPMAPTTYDP MLKVDDSNTRI |
| Tissue Specificity | Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. |
| Post Translational Modifications | N-glycosylated. Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC.this is required for activation and subsequent autophosphorylation on additional tyrosine residues. |
| Function | Tyrosine kinase involved in the regulation of tissues remodeling. It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. |
| Protein Name | Discoidin Domain-Containing Receptor 2Discoidin Domain Receptor 2Cd167 Antigen-Like Family Member BDiscoidin Domain-Containing Receptor Tyrosine Kinase 2Neurotrophic Tyrosine Kinase - Receptor-Related 3Receptor Protein-Tyrosine Kinase TktTyrosine-Protein Kinase Tyro10Cd Antigen Cd167b |
| Database Links | Reactome: R-HSA-3000171 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Discoidin Domain-Containing Receptor 2 antibodyAnti-Discoidin Domain Receptor 2 antibodyAnti-Cd167 Antigen-Like Family Member B antibodyAnti-Discoidin Domain-Containing Receptor Tyrosine Kinase 2 antibodyAnti-Neurotrophic Tyrosine Kinase - Receptor-Related 3 antibodyAnti-Receptor Protein-Tyrosine Kinase Tkt antibodyAnti-Tyrosine-Protein Kinase Tyro10 antibodyAnti-Cd Antigen Cd167b antibodyAnti-DDR2 antibodyAnti-NTRKR3 antibodyAnti-TKT antibodyAnti-TYRO10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
