| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DNAJB2 (215-324) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DNAJB2 |
| Gene ID: |
3300 |
| Uniprot ID: |
DNJB2_HUMAN |
| Immunogen Region: |
215-324 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 215-324 of human DNAJB2 (NP_006727.2). |
| Immunogen Sequence: |
GLELSRREQQPSVTSRSGGT QVQQTPASCPLDSDLSEDED LQLAMAYSLSEMEAAGKKPA GGREAQHRRQGRPKAQHQDP GLGGTQEGARGEATKRSPSP EEKASRCLIL |
| Tissue Specificity | More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level). |
| Post Translational Modifications | Ubiquitinated by STUB1.does not lead to proteasomal degradation. |
| Function | Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins. |
| Protein Name | Dnaj Homolog Subfamily B Member 2Heat Shock 40 Kda Protein 3Heat Shock Protein J1Hsj-1 |
| Cellular Localisation | Isoform 2: CytoplasmNucleusIsoform 1: Endoplasmic Reticulum MembraneLipid-AnchorCytoplasmic Side |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily B Member 2 antibodyAnti-Heat Shock 40 Kda Protein 3 antibodyAnti-Heat Shock Protein J1 antibodyAnti-Hsj-1 antibodyAnti-DNAJB2 antibodyAnti-HSJ1 antibodyAnti-HSPF3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
