| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DRG1 (158-367) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DRG1 |
| Gene ID: |
4733 |
| Uniprot ID: |
DRG1_HUMAN |
| Immunogen Region: |
158-367 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 158-367 of human DRG1 (NP_004138.1). |
| Immunogen Sequence: |
KKIIENELEGFGIRLNSKPP NIGFKKKDKGGINLTATCPQ SELDAETVKSILAEYKIHNA DVTLRSDATADDLIDVVEGN RVYIPCIYVLNKIDQISIEE LDIIYKVPHCVPISAHHRWN FDDLLEKIWDYLKLVRIYTK PKGQLPDYTSPVVLPYSRTT VEDFCMKIHKNLIKEFKYAL VWGLSVKHNPQKVGKDHTLE DEDVIQIVKK |
| Tissue Specificity | High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes. |
| Post Translational Modifications | Sumoylated by UBE2I in response to MEKK1-mediated stimuli. Phosphorylated at Thr-100 by STK16. Hydroxylated (with S stereochemistry) at C-3 of Lys-22 by JMJD7.this modification hinders trypsin-catalyzed proteolysis in vitro. Polyubiquitinated.this modification induces proteolytic degradation and is impaired by interaction with ZC3H15. |
| Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions. |
| Protein Name | Developmentally-Regulated Gtp-Binding Protein 1Drg-1Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 3Nedd-3Translation Factor Gtpase Drg1Trafac Gtpase Drg1 |
| Cellular Localisation | NucleusCytoplasmThe Drg1-Zc3h15/Dfrp1 Complex Associates With Polysomes |
| Alternative Antibody Names | Anti-Developmentally-Regulated Gtp-Binding Protein 1 antibodyAnti-Drg-1 antibodyAnti-Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 3 antibodyAnti-Nedd-3 antibodyAnti-Translation Factor Gtpase Drg1 antibodyAnti-Trafac Gtpase Drg1 antibodyAnti-DRG1 antibodyAnti-NEDD3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
